ID   A0A3B3R2E2_9TELE        Unreviewed;       740 AA.
AC   A0A3B3R2E2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Hypermethylated in cancer 1 protein-like {ECO:0000313|Ensembl:ENSPKIP00000012354.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000012354.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000012354.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A3B3R2E2; -.
DR   STRING; 1676925.ENSPKIP00000012354; -.
DR   Ensembl; ENSPKIT00000036745.1; ENSPKIP00000012354.1; ENSPKIG00000000175.1.
DR   GeneTree; ENSGT00940000161725; -.
DR   OrthoDB; 1378030at2759; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd18333; BTB_POZ_ZBTB29_HIC1; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24394:SF16; HYPERMETHYLATED IN CANCER 1 PROTEIN; 1.
DR   PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT   DOMAIN          51..114
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   DOMAIN          460..487
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          534..561
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          562..589
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          590..617
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          618..640
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   REGION          212..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          718..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..395
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..427
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..734
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  80728 MW;  D5AC462B6DC8D8A1 CRC64;
     MIIKGGIDRM AEESGRPGGG LKTMLDAMEA PSHARHLLLQ LNTQRTKGFL CDVIIVVQNA
     LFRAHKNILA ASSLYLKSLV VHDNLINLDH EMVSPGVFRV ILDYIYTGHL GEDEARSGSG
     TEPSLTAVLA AASYLQLLDL VALCRKKLKH NGKCHLLPTS DAAPYGRLSG TGRCRESTPV
     IQSCFPGGVT NSRVSRGHPP EELAGHPLVP QQGELYAPAP SSPSQQVYPG TPPGLQPQAS
     MHTPRPERVP SPYFGLDLSK KSPESQSQQT PSHPVLSLTH LGAEANGGLG HAGRDSADME
     TEERVGSFSP KSSHPLLGQE LLAHLPHLYR PHALGQEVYS ILPGTGPDAP EDGEGLRGLY
     RWVKREPASY SMEDEEDEEE DEEEEEDDED EDEEERGQEG ARRRRRRKRG GEKLGVSGED
     ERSGSASEET GSSEGRPSPP ETLERFRLAC EPQSFGDNLY VCIPCDKGFP SSEQLNAHVE
     AHAEDVNGAE PPFGQPLAEP GHDEGEVNGP GEVSPVYPGG KRVPAGPGET VRPYRCTSCS
     KSYKDPATLR QHEKTHWLTR PYPCSICGKK FTQRGTMTRH MRSHLGLKPF ACDACGMRFT
     RQYRLTEHMR IHSGEKPYEC QVCGGRFAQQ RNLISHMKMH GVAAAPPRAD LSEAVHPLSR
     YAAERLGLTS DRAAELLSQA SQRLLADTKA SEGLYPLSKL AAQHLGLLHD KMEALRLPTL
     GPPAPTPAPE PRAIGRYSPS
//