ID   A0A3B3R588_9TELE        Unreviewed;       980 AA.
AC   A0A3B3R588;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Rho/rac guanine nucleotide exchange factor (GEF) 18a {ECO:0000313|Ensembl:ENSPKIP00000013932.1};
GN   Name=ARHGEF18 {ECO:0000313|Ensembl:ENSPKIP00000013932.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000013932.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000013932.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; A0A3B3R588; -.
DR   Ensembl; ENSPKIT00000038362.1; ENSPKIP00000013932.1; ENSPKIG00000001069.1.
DR   GeneTree; ENSGT00940000157375; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR13944; AGAP007712-PA; 1.
DR   PANTHER; PTHR13944:SF23; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 18; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          98..295
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          330..439
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          583..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          690..709
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..780
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          806..863
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        738..774
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        834..856
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   980 AA;  110893 MW;  6A9D758DCE87D581 CRC64;
     LQPRAPFLSG RLSNKPISLC HGGAWGATCL GRHMSFDRHC YPGQMNAYNI ADYNIALDAH
     YVDLRADLDS DAQDLELESW SLLVDAPHLQ THPKEVAKRQ DVIYELMQTE MHHVRTLKLM
     AGVYARELRD VLQMDSELLD RLFPRLEDLL KIHVCFLSSL RQRRRDSLEP GGERNYVIQR
     LGDILVLQFS GDIGDWMKQC YGDFCGRHKE AVSFYKEQLQ NNKRFQYLIR KISTLSIIRR
     LTVPECILLV TQRITKYPVL LERLLQSTEA GTEEHEDVSR ALALIRDLLV HVDAQVNEQE
     KASRLRDVAG RMEPRSAGKL KDGRVFRRED LTRGGRVLLR EGPVSWRAAS GRLKDILAVL
     LTDVLLLLQE KDFKFSFCTV DNKLPVISLQ KLIVREVAHE EKAMFLICAS SSEPEMYEIH
     TTSKEERNAW MEHIRQAVEN CPILDEGLGR EHGDLLAMKM KDFREQLSLK DGQIVQSLAE
     KLQIFMEFAE ITGLEESPSC SRLLLRGDST DLQRGEQLLK GAISDVETLM NLLVGTTEPP
     QSQAEGQIVG GKPRRAGTFG GYDRLLAGAG KIFLHAHGCS RVRPRERSQR ASSDPQLKEA
     YAAGPEPPPC PALAVRIRAA VHGNPGSCPP PPPPLRQAVV AQQDSHMELQ RASLWEREQG
     RPGRLRPGTL LEQEKQRNLE KQREELASFQ RLQSRHREEQ ARWERERDRQ RRQAEAVAAA
     LLGREEACRT LEAQTARERR ELDEQRGQYQ QDLERLREST RAVERERQKL EQQQQQQQRR
     EMFNGEFGEL IPYPRPHARP GLPMGFAEDP ERPKVPPRRE SAGLPPVKPE VPPHLLSTTN
     QQGKQPGVQQ QIPTKLAKTK GRPKVAQRCD SAGQSINCVG QLPCPSHTEP RPPHRATPTL
     HIATPTHTEP RLHSGPLSRF AGLSARSSSL AGQVAQDAVV CQHGQAAVEG LLSPLPLWLL
     LLPHFLRVTV LIATLVLLHL
//