ID A0A3B3R7D2_9TELE Unreviewed; 3131 AA.
AC A0A3B3R7D2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rho guanine nucleotide exchange factor 4-like {ECO:0000313|Ensembl:ENSPKIP00000013845.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000013845.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000013845.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPKIT00000038275.1; ENSPKIP00000013845.1; ENSPKIG00000001080.1.
DR GeneTree; ENSGT00940000160622; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 2627..2686
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2722..2906
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 2937..3045
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1754..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..1993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2072..2101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2235..2274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2298..2326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2377..2405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2425..2492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1978..1993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2239..2253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2254..2274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2304..2321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2466..2492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3131 AA; 346613 MW; 658B553F7D6FE3E9 CRC64;
MDDSVAHGTS AGKDGERSPA GDLDEVQMHL TCLPERYMRA KFTLSAYILC WTVLKLCQRL
GCSQTRGQAP ETPEDTANDS EHSQEREPHE WSDLGQETTE EFFDTQSCHS DAFSDLSPDS
EGSSVLLGAR GFHEGEPGER GSSEGHTIPE SMKEESSMDS LCDDLSSRSS PQRCASDQLF
GVLELAEPSG TQEALKSERT LILEAGLPLS SNLQVPETLY STTGSECGPI EISAIHEPLP
HAEVCPLQEF AGTGPSQFVS FSGMGGLVHV EEEEQQQSCS GSQEDHLSED TLGIHQPLSG
LLECLTDDGE DHSAGEARMT SDTGLQNRNK EHPLDCQTEI YTHILTGNEF QLGTSAYTQL
PTVETVLETQ SNTNVPVDSD TVVAFLKDQI DPGTCIQAGN EESDLENKAI ANACVNSAIE
HIFMVDQTTV RENSKDDVVE TLQDTGTKDD VLKSHLQSRT EGNVITDQTE SSTGIKPDNE
EQVSETQDTE INDGLESQPH TNTCAQFDPE NSVLEAFSHS TAAAQSGPEK DVIETEPSSD
AVVLSGTDYR LLETQPNGSV CVQSSTEEDQ NDPNIWIQSR TEEKVLLTQT DTDRYMQSDI
VEDALLTLQD LDTIDDGNKE DISESCSDTC ATDIEETASE IVSLPIQSGP EKDILETESC
SSAHKLADTD DKLLETQPSC NVYVESSAQE DHNDPSSCIL SRTEEKVLPT QMDTDSKIQC
DMEKDDLGTV QDTDNNAQCG TKCALLESKS YVNICLNCDG GHSVSDDQPN VNVSVLSSPE
ELSLSVEGDV LESQVYITAY SQSGTQKNAL CDQTDTSNDI QPDNEGKVLE IVQDTETKEG
VTKGNVSESW PYNKTYAQCD TVLETLPYTN VSTQSGPEND VLDTEPCSDA YMPADIEDKL
LETQPSINVC VQCSADEDQK DPRGFNQLST EEELFKTLCA YSQSVTKDEI LKHPKLPLAN
SNMASCFEED VSEFQIATNY MLSDTGQHVV EKLKETDGRV QCVNEGIVLE NRSHVNSPVN
CESGDDVSDS HPNVNVSVIP GPEEPHCRSI EPSSTTGDGW TCNESDVSRS QASVNAHVQS
SAEDWFSEDQ TDAQHQRKDN VKALQDTDTK DDVMKEDVSE SGFQVRTHLP FGTEGNGISD
LTDRTTGDEK VLEKVQDSET ENDVTRTEVL ERWSLNEACP QSNTKETVIE TVPHCTVAAQ
SGPEKDVIET ELSSDTDILA VSDDTYLETQ PNDNVCVQCV TEEDQEGPSS CIQSRTEEKV
LQIQMEANSY IQPDMEEDAL GTVQDLDWKD DVNKDVSESC NDTCAQITTE ETVLETVSHA
SISTQSGPVK DSLETEMDPS CDAALLAGTD DKLLETHLDG NVLKTESYSD AHILDGDKDY
VLETQLNHKV FDTKEDFLDS SKCSAKVPSI EEDVSQTQSL YSAPTDTEAF EAQPFCNGFG
TEELIEECLP TPHNNHGVIF SNGSQLDNIL GWKSETLPGD EKGEFHISSE DAGIIDSVPQ
NHLDRNFQNL TDLQILFGEA AYAVGFHSIT NKEESIISAV GLDEINFELS ADPQLDKVKQ
CFVDDSEVMS KSGQPSTEMQ IRTNKLESSC ETDFAPDVES PCEDISRACD SGFDEVPEWR
TDIELGTSSQ FEELEWNRTS ESHCAKESPA GSKWHNSNTK SASDLLDPLV QVPKETEHRN
AGGPVDAFSG KGADAVSSES LQSQPEAFGQ HPWLENLSVV VFTNPTDLED EPHWIQQGSE
WRLVVDDLKH CDCSEGEEQG GRGQKTGLRT TDAVGDDPPS NGLAPPPQEV APRNYEISLG
SELEPHNSTS SQMKGLFHEH LDPERYEDKG LRSFVSHSKI IGISDGTREK IGKDQMADRL
RYSVGYHTVP ETEHCSSSQS LLDETEIDVY EQPESNLNLL SGSNLEPILE WDHYQENLFA
LEDKTSVKER EEQQMPVMGS ALVDLKIATS YIDTHPPLTV CLPSTPESSK EDSPDKVTQH
LPASNTTPAL DSSEANTLLA NEKAENKSCY ITNMASQVQD NLNTSREIET EDGLLSHVGN
SSSLQNSVKN KTSKVSTANK ASKFFNRIPS FRKGKTSARE SKSYKGEQAA GNSQDESMER
IKCPPLYQTY LSQSTYHLRE VGESGKNSDD DVFENVVSPR SSFGRRFSET RSRIDEEVFI
PSMQCLRHPT LQDPCDRNSV AIPAMESRSP RRSKSTDNLN LRMRIALAHK SLSSLFESKS
SDKENAVHCP MTINEEASTE TLRGKKRQGS ETEMLKRTLS VSDAGSVRQI QRGSRDRLSL
QISSAKLRSG SQVSCYTDPL SKKAAPRELS DISDERRSEG FRISGPSNGL TLSSSSIICL
ASDSSQVSPD NSNHLTPTNY AQMTTLVHQH APSWARSLGS FEGVDGPLRP QSPKPQSPKP
WPHRRSFRYT SRSVASSLIS LGQGVSAEGL CDPPGRPKTV KPRMAQLAST QSVDTDYRQD
DGVMDSESQD SLATSLSSND TEAPGHRSSS LGQDFSIMPL RDLYFSQSTP IGLDCLGWPR
RVSYPTVVIP DGTLDRAGPS DDVGSEEDLY DEFRSSAHRF GHPGGGGEQL AINEAILRRA
GEGFRFVRLH FLLGPSIHSL IVQLSPGADL LIRTEPFLSS VATLISDGSV CAEALWDHVT
MDDQELGFKA GDVIEVVDAT NKEWWWGRIL DSEGWFPASF VRLRVNQDEP MDYLAKLEGT
REEDGGGVGR LVGPGLPCKE QMRSNVINEI MSTEKDYIKH LKDICEGYIK QCRKRTDMFT
EDQLRTIFGN IEEIYRFQRK FLKGLEKKFN KEQPHLSEIG SCFLEHQTDF QIYSEYCNNH
PNACLQLSKL MKINKYVFFF EACRLLQKMI DISLDGFLLT PVQKICKYPL QLAELLKYTN
PQHRDYKDVE AALNAMKNVA RLINERKRRL ENIDKIAQWQ SSIEDWEGED VLARSSDLIF
SGELTKISQP QAKSQQRMFF LFDHQMVYCK KDLLRRDILY YKGRVDMDQM EVLDLEDGKD
KDFNLSVKNA LKLCSVAAGG EALLLCAKKP EQKQRWLRAF TDERGQVRHD QETGFAITEI
QKKQAMLNAN KSHPAGKPKA VTRPYYDFLL RQKHPTLPTS LPQQQVFMLA EPKRKTSNFW
HNIGRLTPFK K
//
