ID A0A3B3R9M2_9TELE Unreviewed; 736 AA.
AC A0A3B3R9M2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Single-minded homolog 2-like {ECO:0000313|Ensembl:ENSPKIP00000015422.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000015422.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000015422.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3R9M2; -.
DR STRING; 1676925.ENSPKIP00000015422; -.
DR Ensembl; ENSPKIT00000039888.1; ENSPKIP00000015422.1; ENSPKIG00000002154.1.
DR GeneTree; ENSGT00940000159985; -.
DR OrthoDB; 5396877at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR010578; SIM_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF36; SIM BHLH TRANSCRIPTION FACTOR 1B-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF06621; SIM_C; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..53
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 77..140
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 233..288
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 344..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 81198 MW; 929AE45713D3BD10 CRC64;
MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRAVFPDGL
GEAWGHPIRV SPLDNMAREL GSHLLQTLDG FVFVVASDGK IMYISETASV HLGLSQVELT
GNSIFEYIHP SDHDEMTAVL SAHQPLHPHV LQEYELERSF FLRMKCVLAK RNAGLTCGGY
KVIHCSGYLK IRQFVVDMAL YDSCYQIVGL VAVGHSLPPS GITEIKLHSN MFMFRASLDL
KLIFLDSRVA ELTGHEPQDL IEKTLYHHVH GCDVFHLRYA HHLLLVKGQV TTKYYRLLSK
HGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDVEYKDL QLSQDQSSGA KPGLAFKSSL
ASPQDSRKQL KAKAIKIKTK LKSAPYPQPN SSFNQDKTER PPQAWSWKES PPYSLTPCQE
QSPTPEAGAE VLCSAPYGLA FPYAYSHFAA EPAALGGRKP RPGQSPPCQL LGPLQPHGEG
RWGCANARSA KPLHGQALSS SPLPHTATYA GPLAGRRYVS DPTLEDYTGC APSRPNSRFK
EEPFDRSALH QSKAEAGLHV AKGDAKSPVG AAEKAPPGLD RASCEHLKPL QGLGAHLPMQ
VMLEQRRRLC LMESQYGHLG TEHADSNGDR ETPELMEQPQ GGAGRAEEEP RSGFAGVGIQ
NQAPYVSLNF HHVLTKHGSL QGTPNTLAGH LADGYSYRGE QMNPYAYRDQ SPPSSPETHR
EIPHYIGTSV IISNER
//
