ID A0A3B3RAU8_9TELE Unreviewed; 1608 AA.
AC A0A3B3RAU8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Low-density lipoprotein receptor-related protein {ECO:0000256|PIRNR:PIRNR036314};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000015498.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000015498.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers
CC beta-catenin signaling through inducing aggregation of receptor-ligand
CC complexes into ribosome-sized signalosomes.
CC {ECO:0000256|PIRNR:PIRNR036314}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Forms phosphorylated oligomer
CC aggregates on Wnt-signaling. {ECO:0000256|PIRNR:PIRNR036314}.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|PIRNR:PIRNR036314}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR STRING; 1676925.ENSPKIP00000015498; -.
DR Ensembl; ENSPKIT00000039965.1; ENSPKIP00000015498.1; ENSPKIG00000002174.1.
DR GeneTree; ENSGT00940000158990; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0042813; F:Wnt receptor activity; IEA:InterPro.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR017049; LRP5/6.
DR PANTHER; PTHR46513:SF40; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 12.
DR PIRSF; PIRSF036314; LDL_recpt-rel_p5/6; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 16.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|PIRNR:PIRNR036314};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR036314};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR036314};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|PIRNR:PIRNR036314};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR036314};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR036314};
KW Wnt signaling pathway {ECO:0000256|PIRNR:PIRNR036314}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|PIRNR:PIRNR036314"
FT CHAIN 20..1608
FT /note="Low-density lipoprotein receptor-related protein"
FT /evidence="ECO:0000256|PIRNR:PIRNR036314"
FT /id="PRO_5017106892"
FT TRANSMEM 1372..1393
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR036314"
FT REPEAT 63..107
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 108..150
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 151..194
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 195..237
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 286..325
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 373..415
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 416..458
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 459..502
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 503..545
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 592..629
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 675..717
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 718..760
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 761..803
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 844..886
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 893..931
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 978..1024
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1025..1067
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1068..1112
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1113..1155
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1205..1249
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1454..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1549..1608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1462..1478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1269..1284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1287..1299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1294..1312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1306..1321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1325..1337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1332..1350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1344..1359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1608 AA; 179029 MW; 0DDC8ACAC9417942 CRC64;
MGALLRTLLC CSFCSLMRGE PLLLYANRRD LRLVDVAQGG SNATVLVSGL EDAAAVDFVF
AQSFLYWSDV SEEAIKRAAF NWSGSSQQST VLSGLQSPDG LACDWLGSKL YWTDSEANRI
EVANLDGSLR KVLFWQELDQ PRAIAVDPAR GFMYWTDWGE IPKIERAGMD GTSRSVIVDK
NIYWPNGLTL DYDQKKLYWA DAKFNFIHRS DLDGSLREVV VKGSLPHPFA LTLYRDTLFW
TDWNTHSIHS CNKYTGEDQR EVHTNIFSPM DLHAYSQERQ PHVSGPCMVG NGGCSHLCLL
SPVKPFYQCA CPTGVQLLED QRTCRQGATQ ILLLARRTDL RQISLDTPDF TDVVLNMDDV
RHAIAIDYDP VEGLVYWTDD EVRAIRRSRL DGSSSQFVVT SQVSHPDGIA VDWVARNLYW
TDTGTDRIEV TRLNGTMRKI LISEDLDEPR AIVLDPTAGY MYWTDWGEIP KIERAALDGT
DRVVMVNTSL VWPNGLALDY TERKIYWADA KTDKIEEMNM DGTGRRVLLD DKLPHIFGFT
LLGDFIYWTD WQRRSIERVH KSSAEREVIV DQLPDLMGLK ATYMHKTIGT NPCAENNGGC
SHLCLYRPQG VQCACPIGLE LIGDMSTCIV PEAFLLFSRH TDIRRISLET NNNNVAIPLT
GVKEASALDF DVTDNRIYWT DITLKTISRA FMNGSALEPV VEFGLDYPEG MAVDWLGKNL
YWADTGTNRI EVAKLDGQHR QVLVWKDLDS PRALALDPAE GFMYWTEWGG KPKIDRAAMD
GTGRVTLVPN VGRANGLTID YAERRLYWTD LDTTLIESSN LLGMEREVIA DDLPHPFGLT
QYQDYIYWTD WSQRSIERAN KTSGQNRTVI QGHLDYVMDI LVFHSSRQAG WNACASTNGH
CSHLCLAVPV SGFVCGCPAH FSLNNDNKSC SAPTSFLLFS QKTAISRMVV DEQQSPDIIL
PLHSLRNVRA IDYDPLLRHL YWIDAKQNAI RRAQEDGNQS ISVVSGSLGG LGLQPFDLSI
DVYSRFIYWT SDVTNVINVT HIDGHGVGVV LRGEHDRPRA IVVNPERGYM YFTNLQERSP
KIERAALDGT EREVLFFTGL GKPVALAVDN EASRLFWADA DLRRIESSDL TGANRVVMED
SNILQPVGLT IFENHLYWID RQQQMIERID KNTREGRTKI QARISSLSDI HAVHALDMKE
YSKHPCTSDN GGCSHICIVK GDGTTRCSCP VHLVLLQNEL SCGEPPTCSP EQFSCAFGDV
DCIPQAWRCD GIAECEDGSD ERDCPVCSPL EFQCASRQCV ALGLRCDGEA NCQDASDESE
CTAHCPVDQF SCANGQCVGK HKRCDHNMDC TDNSDELGCY PTEEPPPPPT SAVGSIVGVV
LALFVVGAIY FVCQRVFCPH AKDDGEASDF VVHGPSSMPL GYVPHPNSLS RSLPGMSRGK
SVMGSLSIMA GSSGPPYDRA HVTGASSSSS SSTKGSYFPP VLNPPPSPAT ERSHYTMEFG
YSSNSPSTHR SYSYRPYTYR HIAPPTTPCS TDVCDSDCTP GRRIIAPAKG YTSDLNYDSE
PFPPPPTPRS QYLSAEENCE SCPPSPYTDR SYSHHLYPPP PSPCTDSS
//