ID A0A3B3RAX1_9TELE Unreviewed; 1087 AA.
AC A0A3B3RAX1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=NLR family CARD domain containing 3 {ECO:0000313|Ensembl:ENSPKIP00000015837.1};
GN Name=NLRC3 {ECO:0000313|Ensembl:ENSPKIP00000015837.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000015837.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000015837.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; A0A3B3RAX1; -.
DR Ensembl; ENSPKIT00000040315.1; ENSPKIP00000015837.1; ENSPKIG00000002323.1.
DR GeneTree; ENSGT00940000159861; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 10.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 12.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..130
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 190..321
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1087 AA; 121206 MW; CDA9EAC939959827 CRC64;
QERKTHTASY RDHIQKRIPW EEDCYIDLQS ESCSPRTKMK MEELWIHKHR KQLLHSVSGP
LLDSFVGHMH KVALLTQGEA SQLQSGGQLQ EKLCAVINIL ASKGPQGSDM LQEFIENTDT
QLYGLITLQG SWAADRFSNL LLVEGLTDLQ QKEHDVLQTE ATKGSWRHNA RQLSLDKLLN
PLTRVSMPPR ILLTVGVAGI GKTTLVRQFL QLWNSGKIYQ DVSFVFLFSF WELNTYEKLS
AERLVRLFYP HVTDMSYVFN DTTRVLIIFD GLDEFKCSLD FSDALSCMDP KKDVPVDNLI
TNIIRGNIFP EASIWLTSRP NVAAQIPGGL VDRMTEIPGL KHEDIQKFLF HMFQDRSLAD
QIWCHIKAYK IFLVMCYVPC VCWIVGSTLG FLIKGEMQDC LPRTWTELYS YFLKMIVEGE
SKDREPLKIE QSYGSSRRLI GSLGKLAFYG LIKRKYTFYE QDMKAYGIDL PSLQSHPCSR
LLIKEESVTC TAYNFTHLTV QEFLSATFYY TASKRAIFDL FTESGMSWPK IGFNNHFKSA
LQRSQQSECG QLDMFVRFLS GMLSPLVAKP LSGLQLLAKE ENSAYRAPAI TFLQSLLSCG
STVSLWAVNV VHCLQELQHT ELTRNVEEGL RTGSLAGKLS ASTCSILAYL LQMSEECAEE
TNLSGCLSYS VVKSLLPQLL FCSNLRLENN HFKDDVMELL GSLLSAKDCH LQRISLAENA
VSNKGTKAIS RSLLVNRSLT SLDLRSNNIG PKGAKSLAEA LKNNQVLVSI SLQNNVIEDE
GTKALAEVLL CNRKLTTLHL QKNSIGSEGA RSLAGALQKN QVLRELSLSS NQLGDKGSEA
LAQALMVNHS LITLHLQSNS ISNKGVTALT KALKINRGLA DLNLRENSIG VEGAKEIAKA
LQTNGTLKNL DLTANLLHDE GAKAIAKAVQ FNCALTSLHL QWNFIRSTAA QALAAALTTN
TALQLLESVF LRFPSKPLSL SYHLFHCFVI MYKNIYFLFY FSLRGNSIGM EGAKALANAL
KANSSLRVLN LQENALGMDG AIFIATALNR SHQLTYINLQ GNRIGDSGAK VISDTIKTRS
PECVVKI
//
