ID A0A3B3RB91_9TELE Unreviewed; 4701 AA.
AC A0A3B3RB91;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSPKIP00000015180.1};
GN Name=RYR2 {ECO:0000313|Ensembl:ENSPKIP00000015180.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000015180.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000015180.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR STRING; 1676925.ENSPKIP00000015180; -.
DR Ensembl; ENSPKIT00000039640.1; ENSPKIP00000015180.1; ENSPKIG00000001852.1.
DR GeneTree; ENSGT00940000154906; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 2.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 3.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4061..4080
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4257..4275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4315..4334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4502..4523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4578..4601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..150
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 246..303
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 554..764
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 954..1147
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1193..1412
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3806..3841
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 2196..2216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3992..4014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4116..4139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3994..4012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4121..4139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4701 AA; 534319 MW; A3C11F023630A8DF CRC64;
MTRDKCESTY YTSTRDEGNK EQVRDDEVVL QCSTTIHKEQ QKLCLAAEGF GNRLCFLEST
SNSKVRLSPT KFTLPLLQVY LPARIFSQTA QGGGHRTLLY GHAVLLRHSY SGMYLCCLST
SRSSTDKLAF DVGLQEDTTG EACWWTIHPA SKQRSEGEKV RVGDDLILVS VSSERYLHLS
YGNGSLHVDA AFQQTLWSVA PICSGSEVAQ GYLIGGDVLR LLHGHMDECL TVPSGEHGEE
QRRWSGSHIR WGQPFRLRHV TTGKYLSLTD DRGLLLMEKE KADVKSTAFC FRSSKEKLDF
GARKEVDGMG VPDIKYGDSV CYVQHVDTCL WLTYQAVDAK CARMGGVQRK VAIMHHEGHM
DDGLTLSRSQ HEESRTARVI RSTVFLFNRF ISKKGKTSTL DLPIESVSLS LQDLIGYFQP
PDEHLEHEDK QNRLRALKNR QNLFQEEGMI NLVLECIDRL HVYSSAAHFA DVAGREAGVA
WKSILNSLYE LLAALIRGNR KNCAQFSGSL DWLISRLERL EASSGILEVL HCVLVESPEA
LNIIKEGHIK SIISLLDKHG RNHKVLDVLC SLCVCHGVAV RSNQHLICDN LLPGRDLLLQ
TRLVNHVSSM RPNIFLGISE GSAQYRKWYY ELIVDHVAPF VTAEATHLRV GWATTDGYSP
YPGGGEGWGG NGVGDDLYSY GFDGLHLWSG CVARTVSSPN QHLLRADDVV SCCLDLSAPS
ISFRINGQPV QGMFENFNSD GLFFPVVSFS AGVKVRFLLG GRHGEFKFLP PPGYAPCFEA
VLPREKLRVE HSQEYKQDHS GTRDLLGPTI TLTQAAFTPT PVDTSQIVLP PHLERIREKL
AENIHELWVM NKIELGWTYG TIRDDNKRQH PCLVEFCKLP EQELLLQAVH YLLDKEHSRR
KTSSCKCYEL SSGYKPAPMD LSHIKLSSSQ EAMVDKLAEN AHNVWARDRI RQGWTYGIQQ
DVKNRRNPRL VPYALLDERT KKSNKDSLRE AVRTLLGYGY NLEAPDQDHE RFRIFRAEKT
YCVNAGKWYF EFEVVTAGEM RVGWARPDCL PDWELGSDDQ AFVFDGFKAQ RWHQGNEHFG
RSWQPGDVVG CMVDMNEHTM MFTLNGEVLL DDSGSELAFK DFEVCFIPVC SLGVCQLGRM
NFGKDVSTLK YFTICGLQEG FEPFAVNMNR DLTMWLSKRL PQFIPVPQNH EHIEVARIDG
TIDGSPCLKV TQRSFGSQNS NTDIVFYRLS MPVECAEGFS KSPGATLPSN GSFFSPKKDL
DDFETVSDFE VLMKTYYYSV RIFPGQEPSS VWVGWVTSDF HQYDTAFDLE KVRTVTVTLG
DEKGKVHESI KRSNCYMVWA GESTSPGQGR NNNGLEIGCL VDTANGLLTF TSNGKDLSTY
YQVEPSTKLF PAVFAQATSP NVFQFELGRI KNVMPLSAGL FKSERKNATP QCPPRLHVQF
LTPVLWSRVP NHFLKVEASR VNDRHGWLVQ CSEPLQFMSL HIPEENRSVD ILELTEQKDL
LKFHFHTLRL YSAVCALGNN RVAHALCSHV DEAQLLYAIE NKYMPGLLRT GYYDLLIDIH
LSTYATARLM MNNEYIVPMT DETKSITLFP DEKKKHGLPG IGLSTSLRPR MYFFSPSFVR
GGGDFFQYSP EFPLDILKTK TIEMLTEAVQ EGSLHARDPI GGSTEFLFVP LIKLFYTLLI
MGVFHNGDLK NILQLIEPSV FSEDSGHEGG DTPDCESFKG ELRIEGTGGE ETGRTGKVPK
EGLLQMKLPE PVKLQMCHLL QYLCDCQVRH RIEAVVAFSD DFVANLQDNQ RFRYNEVMQA
LNMSAALTAK KTKEFRSPPQ EQINMLLNFK DEKQDCPCPE DIREQLLDFH EDLMTHCGKP
RIRPTRSTSR ILCDVAPAWL RICKRCDALC PSKRSSDRTL QQLISETMVR WAQESVIEDP
ELVRAMFVLL HRQYDGIGGQ VRALPKTYTI NSVSVEDTIN LLASLGQIRS LLSVRMGREE
EKLMIRGLGD IMNNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGESKEIT FPKMVANCCR
FLCYFCRISR QNQKAMFDHL SYLLENSSVG LASPSMRGST PLDVAAASVM DNNELALALR
EPDLEKVVQY LAGCGLQSCM MLVSKGYPDI GWNPVEGERY LDFLRFAVFC NGESVEENAN
VVVRLLIRRP ECFGPALRGE GGNGLLAAME EAIKISEDPT RDGPSPTSDS DMLEEEEDDT
IHMGNAIMTF YAALIDLLGR CAPEMHLIHA GKGEAIRIRA ILRSLIPIED LEGVISIPFP
MPTLAKDGTV VEPDMSAGFC PDHKAAMVLF LDRVYGIEDQ NFLLHLLEVG FLPDLRAAAS
LDTAALSATD MALALNRYLC TAVLPLLTKC APLFAGTEPY ASLIDSLLHT VYRLSKGCCL
TKAQRDAIEE CLLSMCGKLR PSMMQHLLRR LVFDVPLLNE HAKMPLKLLT NHYERCWKYY
CLSGGWGSFG AASDEELHLS RKLFWGIFDA LSQKRYDLEL FKLALPCLSA VAGALPPDYM
ESNYVAMMEK QSSMDSEGNF TPQPADTSNV TVPEKLDCFI NKYAEHSHEK WSTDKVMSLA
LYFCVMGGYH GMYLIITFKR DKEVYRWPIK ESLKTMLAWG WTIERMREGE TVGLHNRARR
VSQSSTHGFT PRPIDMSNVT LSRDLHSMAE LLAENYHNIW AKKKKMELES KGGGSHPLLV
PYDTLTAKEK AKDREKAQDI LKFFQINGYT VSRAMKEQEL DTPSIEKRFA YTFLQQLIKY
VEEAQEQMME FDVGTRPKGE KISHEQQMFF GKVVLPLVDQ YFKNHRLYFL STAIRPLSSG
GHASNKEKEM VTSLFCKLGV LVRHRISLFG KDGSRTHLLA CWVGLPRTVM KTGLDMVKAA
LRAFFDDAAE DLEKTMENLK QGQFTHTRSQ PKGVTQIINY TTVALLPVLS SLFEHIGQNL
FGEDLILDDV QVSCYRILNS LYSLGTSKSI YVERQRPALG ECLAAFSGAF PVSFLEPYLN
KYNTYSIYNT KGSRDRTALG LPAQVEEVTP LIPSLEKLLE EIMELAESGV RYTQMPHVME
VVLPMLCSYM SHWWEYGPEG SPETAEHCCT SLTSDHMNTL LGNILKIIYN NLGIDEGAWM
KRLAVFSQPI ISKAKPQLLK THFLPLMEKL KKKAATVLLD EESMKAEGRG EMSEAELLIL
DEFTILVRDL YAFYPLLIRF VDYNRAKWLK EPNPEAEELF RMVAEVFIFW FSHNWKFTLA
AFILVNTIID HSVSDQERKK MKKKGDRYSM QTSLIVAALK RMLPVGLNIC APGDQELIAL
AKNRFTQKDT EDEVREIIRN NLHLQGKLED PAIRWQMALY KDLPNRNEDT TDPEKTVERV
LDISHVLFHL DQVEHPQRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR HRAVNLFLQG
YAKSWIEAEE HYFEDKLIED LAKPGDEEPA EEDEGVKRID PLHQLIQLFS RTALTAGLSS
WSMQEKEMEK QKLLYQQARL HDRGAAEMVL QTISASKGEM GPMVASTLKL GIAILNGGNS
TVQQVRRLPR SRSVQPYHTL GPRSLLTRTC PLPFSVLDLN AFERQNKAEG LGMVTEEGSG
TRALPRERTR KVMQDDEFTC DLFRFLQLLC EGHNSDFQNY LRTQTGNNTT VNIIISTVDY
LLRVQESISD FYWYYSGKDV IDEQGQRNFS KAINVAKQVF NTLTEYIQGP CTGNQQSLAH
SRLWDAVVGF LHVFAHMQMK LSQDSSQIEL LKELMDLQKD MVVMLLSMLE GNVVNGTIGK
QMVDMLVESS NNVEMILKFF DMFLKLKDLT SSDAFKEYDP DGKGVISKRD FHKAMESHKH
YTQSETEFLL SCAETDENEL LDYEEFVERF HEPAKDIGFN VAVLLTNLSE HMPHDTRLQT
FLELAESVLN YFQPYLGRIE IMGSAKRIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV
NEGGEKEKME LFVNFCEDTI FEMQLAAQMS DAGERSASKE ESEKEKPEEE NPDMGFFSVT
TVRTALFALR YNVMLLMKVL SMKSLKKQVK KVKKMTMKDM VMTLISFYWS VLMGLFHFTF
SVSRGFFRIM YSTFLGGSLV EGAKSMKVAD LLANMPDPTQ DEVRGEGEEG EKRLTDRSSA
QEDLADLAVA TEDSELLSDI FGLDLRREGG QYKLIPHNPN ASLSDILTPP TPAKEKEESK
CEPEKAECEA ACRSLGFLFS FSFFFKSIFT PEAPAPVLTR LLSLQNYFAR NFYNMRMLAL
FVAFAINFIL LFYKVSETPD PRVRWTPVDN IPHQPVTVHF VLEESSGYME PTLRILAVLH
TVISFFCIIG YYCLKVPLVI FKREKEVARK LEFDGLYITE QPSEDDIKGQ WDRLVINTQS
FPNNYWDKFV KRKVVHNLTC VSVLYPCLGF DCILIRQCAL NHFEWILLVD RLNSIDVKYQ
IWKLGVVFTD NSFLYLAWYM TMSILGHYNN FFFAAHLLDI AMGFKTLRTI LSSVTHNGKQ
LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDGESPDMKC DDMLTCYMFH MYVGVRAGGG
IGDQIEDPAG DEYEIYRIIF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET
KCFICGIGND YFDTVPHGFE THTLQEHNLA NYLFFVMYLI NKDETEHTGQ ESYVWKMYQE
RCWEFFPAGD CFRKQYEDQL N
//
