ID A0A3B3RCL0_9TELE Unreviewed; 1333 AA.
AC A0A3B3RCL0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Enhancer of mRNA-decapping protein 4 {ECO:0000256|ARBA:ARBA00015762};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000015655.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000015655.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
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DR Ensembl; ENSPKIT00000040125.1; ENSPKIP00000015655.1; ENSPKIG00000002209.1.
DR GeneTree; ENSGT00510000047791; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 43..368
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT REPEAT 221..254
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1203..1323
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 403..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 879..957
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 775..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1333 AA; 145365 MW; 5BF84F6D9E997541 CRC64;
MSCQDPQIIC LSGDDSSTRV TISSSVVEIV ASHNSSINSK ACGSNKVKIK PVAKYDWEHK
YYYGSLIAVS NSYLAYAIRG ANNCAMIRVL SQCTAERTLL KGFTGAVADL AFAHLDSSQL
ACLDEAGNMF IWQLSCSAGK IQDEILVHIR RPADTPLSSN RRLIWCPFIP EENEEGPEES
CQTLALLHED RAEVWDLDIL RSTQHSWPVD ASDLKEGFIV VRGHSGRISE GVLSPDGTVL
ATASHDGFLK FWQIYIEGQD QPRCLHEWKP HDGRPLSCLL FCDNHKKQDP EVPFWRFLIT
GADQNRELKM WCTVSWTCLQ TIRFSPDPFN SIVLPSLKVA LDLSAGYLVL SDVQRKVLYV
MEVQQNQEKG RARFTAVSEF LLTHPVLSFG LQDVSCCRLQ PSEVLPPDED SESMTTEGSQ
GGLAESKTGV QIHLYCIHTK CLQDVQIWFQ PHVTPSTSLL LPPSDSQEDF GCCELLADTN
TEGPASDKES GRPSQGDLRR VPSLPIPADF LPPSEGTKPT LMTPDAFMTP TASIPASPGS
SVSSLTVVTA MSSSSTSGRT GEELTQSSKV SLESSALALG SASGSGSSSA SGSAHSSPRS
SSILIPGLGD QMNSSNIQVA APLNPPLSLD LQAIEPLLVP QASPTRERSP DVISSASTAM
SLDIPEIASE TLPRVGVPPL APEVRSPALH SDSMASAASA LHLLSPRNRS GSEHGRPSLD
LGGGGGAGGG GATADGERLS ATPSLLEAAL SQEGAAACPL EPSVSWPAAP DITRETRDSL
ADCSRDEMKD KHKTSPFHRH SYGLPLNDSQ DASAEQSDHD DEVASLASSS GNCASRTSHR
LPVKDWKVSP RSSPKLKKKC RKDDGESLQS RQPDQLMGLD TQEEVLQMLR SQQRELSELR
QSQLELMQRL TASMDAIQSS VLAIVEQAMI NQQEQSQRRM ERMMAEGREQ NRQLQEHLSQ
QVTQNLSTAL CGRMDKLLRE EMKKSIPQAI SKSLDPVTGQ MNSTIAAKLT AVEGALKENV
TKVVKSKNTT DAIGKAAAEA MQGPIQAAYK EAFQGIVLPV FEKGCQSMFQ QINDSFKQGT
HEYIQQLESH LKNKKQRELE ARDPLIGQLQ QMVDTLQSST DQLAATVTAS VRSEVQHQLH
IMVGNLQDSI LTQVQRIVKG EVSLAMKEQQ AAVTSSIMQA MRSAAGTPVP PALLDYQAQQ
QNVLQLLQQG QFNQAFQQAL SAADLNLVLY VCETIDSQQV FSQHPCPLIQ PVLLSLIQQL
STNLTTRSEL KISYLEDAVM NLDHSDPVTR DHMSSVLTQV RQKLFQFLQL DPHSPLSKRA
RRLMMMLQGL VTQ
//
