ID A0A3B3REL7_9TELE Unreviewed; 368 AA.
AC A0A3B3REL7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase {ECO:0000256|ARBA:ARBA00016378};
DE EC=3.6.1.13 {ECO:0000256|ARBA:ARBA00012453};
DE EC=3.6.1.16 {ECO:0000256|ARBA:ARBA00012443};
DE EC=3.6.1.53 {ECO:0000256|ARBA:ARBA00012529};
DE AltName: Full=ADPRibase-Mn {ECO:0000256|ARBA:ARBA00032579};
DE AltName: Full=CDP-choline phosphohydrolase {ECO:0000256|ARBA:ARBA00030848};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000016839.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000016839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+);
CC Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215;
CC EC=3.6.1.13; Evidence={ECO:0000256|ARBA:ARBA00001454};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+);
CC Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215;
CC EC=3.6.1.53; Evidence={ECO:0000256|ARBA:ARBA00001583};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP-choline + H2O = CMP + 2 H(+) + phosphocholine;
CC Xref=Rhea:RHEA:32487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58779, ChEBI:CHEBI:60377, ChEBI:CHEBI:295975;
CC EC=3.6.1.53; Evidence={ECO:0000256|ARBA:ARBA00001789};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate;
CC Xref=Rhea:RHEA:21692, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57597, ChEBI:CHEBI:58311, ChEBI:CHEBI:60377; EC=3.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001209};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the ADPRibase-Mn family.
CC {ECO:0000256|ARBA:ARBA00006362}.
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DR AlphaFoldDB; A0A3B3REL7; -.
DR STRING; 1676925.ENSPKIP00000016839; -.
DR Ensembl; ENSPKIT00000041340.1; ENSPKIP00000016839.1; ENSPKIG00000002994.1.
DR GeneTree; ENSGT00390000014667; -.
DR OrthoDB; 276166at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0047734; F:CDP-glycerol diphosphatase activity; IEA:UniProtKB-EC.
DR CDD; cd07396; MPP_Nbla03831; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041869; MPP_ADPRM.
DR PANTHER; PTHR16509; -; 1.
DR PANTHER; PTHR16509:SF1; MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 48..314
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 368 AA; 42733 MW; 54CFDCE3B3ED27F2 CRC64;
MFNFKCPFRN KCVSERRVVG WWTKHEGLSS RLISRASKMD DSIQPLFTFG VIADIQYADI
DDGYNFTHTR KRYYRNSLQL LRRANEKWKT ETVQPSFILQ LGDIIDGFNK KYEASQKALD
TVLTEFDRTG IAVHHVWGNH EFYNFSRQDL ITSLNSQNTD FAMREDEIKQ KHPDNEQSYA
YHFSPAPNFR FVVLDAYDVS LIGRQENSEQ YNQALKILQE HNGNYDLNQP PAYSGLEQRF
VKFNGGFGQD QLEWLDRLLS LSDQKLEKVT IVSHLPIHPS STDPVCLAWN YDDVLSILYS
HKSVVCFMAG HDHDGGYHQD ISGIHHLTFE GVIETRPNND AFGTVYVYED RMKLKGNGRV
PHRSLNYE
//
