ID A0A3B3RG14_9TELE Unreviewed; 1865 AA.
AC A0A3B3RG14;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=DENN/MADD domain containing 4C {ECO:0000313|Ensembl:ENSPKIP00000017547.1};
GN Name=DENND4C {ECO:0000313|Ensembl:ENSPKIP00000017547.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000017547.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000017547.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPKIT00000042059.1; ENSPKIP00000017547.1; ENSPKIG00000003318.1.
DR GeneTree; ENSGT00940000158215; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT DOMAIN 38..197
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 189..639
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 946..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1523..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1523..1550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1865 AA; 206097 MW; 55D20622C745C342 CRC64;
MIEDKGHRVT DYFVVAGLTE KSTPIEQDLS ETKSSGPKAP ITDLAVINRS AGETVPEGFT
CVEITPGGQP ANLNHGSLKS PELFLCYKRG REKAPLIDIG ALYEGKERLI PGCEVIQATP
YGRCANVNNS SATSQRIFLT FRRAPAVRPQ NTLAVTDVCV IIGSKGETPP HTFCKVVKNL
NAGMWGSSVF LCYKKSVSSS NSIPYTAGLI FRYPAEDYES FPLSESVPLF CLPMGARIEC
WEPNTRYPLP IFSTFVLTVS SGEKMYGAAI QFYEKYSLEL LNEKQKVQLG LLSVVDKRPI
PNRLVNTNKC ICLLSRWPFF ESFRKFLMFL YKLSVSGPHP LPIEKHISHF MHNVSFPSPQ
RPRILVQLSA HDSLILSQPV CTPLPLSGAD FRTLLSNLGA EHCATVLHFV LMESKILLHS
LRPDVLTGVA EAVVAMIFPL QWQCPYIPLC PLSLAGVLNA PCPFIVGVDS RYFDLYEPPP
DVVCVDLDTN TVYLSDEKRN CNWKNLPKKP SKNLLNSLGS LYHQLTTVLK TSSEEQVLDM
APMEADFTWH RRKTGLEMEV QEAFLRFMAS ILKGYRSYRK PITQAPSEKA TALDSLYDLQ
GFLKSRDRAQ QKFYTQLTKT QIFIRFIEEC TFVSDKDTGL AFFDDCIDKL FPSDKVTDKG
AKMEGETVED TRLIEMDESQ NSDLTVFVMP PEPPTEEGEV PVVRYSYENF PRLRLELFDC
PQELRPALSR RTAGASVSSS PALLSKRTKQ EIKLAYKMAK RYYSHPPLWA KCLFSHCYSL
WFICLPAGVR ASRSKLHAMQ QAYNVLLKMQ STEVEVLDEV CYRVVMQLCG IWGLPVMAVR
VLMAIKKAGV EPNAITYGYY NKAVLEGPWP SQNRSGRFRW AKVRNVVRAM AHFRQAIAAG
RAKGCAGAMA ASSDMHDVDH ISHGSADSSS DVNGEEHTLF ARNLVVPDGT DNHGSTGGQS
DQGYGSKDEL HQEVLDVLGL PAPSCSELPS KIKAPNTGVD GGKLFTFRSP SEEVALPDVG
GALVLGGGTR EASSQLQRQR AFSERSCSFS VESRAGMLLK KGSLEKSVDQ MVTEMGADAK
ILAAALSGNK TPPPEPMDLS EKGLRHSHSR QLGEDSVFPE VKELAESTGL LVDIAQQNPV
AKMDPEVVRR KEVKYGNPSK RNSSHSRVVE REDVEKGADP LSIMATADEE SLSVRSEEPV
ASVASRRLAD EIEMYMSLKS PLGTKSSSME FHQEAAKQVP ADTAAQNKSL ERRSSLPADP
IKQPGSDSGT SKRSPAVPRS KTFMAKPKNQ TQRSSSLSAL VRSSPSGSLG SVINSISAIK
MDSLLPAHKL DTFKSGMKQA ANVASRVWGA VSSVYNFSDD EDDHPQGDGC FPARLDENLL
EESGRAGSGP RALMPGLTSS ELTQSRTSLS STSSSDTTRV SHPAHMTPGK PLRGSESEKL
EQGSSHHASS SSIYQNCALE VLMSSCSKCR SCEALVYDEE IMAGWTADDS NLNTTCPFCK
TTFLPLLYVE FRDLRGTSSF LLKPSTSGDS INSSNNVPSS SLSTEPSRDP TDLISFDEDP
GGKPPDVHES SGSEDIRVDL PEGKRSTSLT RSNSVSGPLQ SLELNQRPSH GVSTNSLPSS
LQEASDALGQ KRPNPLPVSV PYLSPLVLRK ELESLLENEG DQVIYTHKFL SQHPIIFWNL
VWYFRRLDLP SNLPGLIITS EHCNNGVQLP LTSLSQDSKQ VYVQLLWDNI NLHQDPTEPL
YQLWRMFLRM KGQLSPTDYQ ETRSLLNSIV RSIQGNSVST PIDLLLQEVK KHPEVKRRRS
IYREILFLAL VALGPEYIDI EAFDREYKQA FNELSPEKMK ALAPIDQPPV NSVQWCLKCF
GSLVI
//
