ID A0A3B3RH24_9TELE Unreviewed; 941 AA.
AC A0A3B3RH24;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000017648.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000017648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3B3RH24; -.
DR Ensembl; ENSPKIT00000042164.1; ENSPKIP00000017648.1; ENSPKIG00000003475.1.
DR GeneTree; ENSGT00940000164173; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF32; CADHERIN-RELATED NEURONAL RECEPTOR VARIABLE 10-RELATED; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..941
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017258932"
FT TRANSMEM 688..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..130
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 131..239
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 240..346
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 347..451
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 452..561
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 568..673
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 899..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 102788 MW; 3162FCB5EAC7A88A CRC64;
MGDVIHVKCV RIWLLTLLCL WDPSSGQIVY SVSEEVNKGT VVGNIAKDLG LKGNDLEPRM
FQLVSGSSRK YFEVNLKTGV LFVNERLDRE ELCPGAQKCN LFLEAIIHNP LNLYRVEINI
LDVNDNAPFF PRNKIELNIT ENATPGDQFS ILMAEDPDVG SNSLKTYKLS PNEHFTLDGQ
GGGEQSASAE LVLQKALDRE KQATIPLVLT AIDGGKPPRS GTLHIIVNVM DVNDNSPVFN
KPLYKIQLDE NVPYGTPVIT LNATDLDEGL NSLIQYSIVE HKSVHLDTFN ADPHTGRITV
KGRIDYEENP AFEIRVEATD NGVPPRSTQC KVLIEVIDLN DNRPEISVTP LLKSLREDAK
SATAVALITL SDKDTGKNGM LKFEIIGPSP FKLQSSFKNY YSLVVDGPLD REKVSEYNVT
IIATDEGTPP LSSTSVITVH VSDVNDNAPR FPEPLINIYV KENNQIGIVI YTVSAADPDE
NENARVSYSL IEGSSASVPL SSVINVNSAS GEIYSLQSFN YEEMKTFQFQ IRATDSGEPP
LSSNVTVKVF ILDENDNSPG ILLPYSDQGS VSTESIPYSA EAGYFVAKIR AVDADSGYNA
LLSYHIAEPK GSNLFRIGTS SGEIRTKRRM SDNDLKTHPL VILVSDGGDP SLSATVSIDV
VVVESNSEIQ THFRHLPTKE ESFSDLNLYL LIAIVSVSVI FLLSLISLLA VKCHRTDTSL
SRYSAPVITT HPDGSWSYSK STQQYDVCFS SDTLKSDVVV FPAPFPPADA ELISINGADS
LKRNQTLPTR EKPKAPNADW RYSASLRAGM QSSVHMEESS VMQGAQGVLV QNWPTVSSAA
GDGEGGEHSP PVGAGINSNS WHFRYGPGPG YGPPQHLKPG EVPEAFLIPG SPAIISIRQD
QAGIDDKGDF ITFGKKEETK KKKKKKKGKD KKDKGKDDGD E
//
