ID   A0A3B3RIC9_9TELE        Unreviewed;       841 AA.
AC   A0A3B3RIC9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Discs, large homolog 2 (Drosophila) {ECO:0000313|Ensembl:ENSPKIP00000017446.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000017446.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000017446.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3RIC9; -.
DR   Ensembl; ENSPKIT00000041958.1; ENSPKIP00000017446.1; ENSPKIG00000003247.1.
DR   GeneTree; ENSGT00940000155156; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12032; SH3_DLG2; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR035759; DLG2_SH3.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM01277; MAGUK_N_PEST; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          123..210
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          218..305
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          392..473
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          507..577
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          651..826
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
SQ   SEQUENCE   841 AA;  93881 MW;  1424C4D29F0DD1DB CRC64;
     MDCLCIVTTK NRPAAVQASP HTAQPPPACM NPALMSAPWY RYQDEDSPPQ DHGFPRLTNE
     ARAPELVHVS EKNLSEIENV HGYVSHSHIS PLKASPAPII VNTETLETVP YVNGTEIEYE
     FEEITLERGN SGLGFSIAGG TDNPHIGDDP GIFITKIIPG GAAAEDGRLR VNDCILRVND
     ADVSEVSHSK AVEALKVAGS IVRLYVRRRR PMLETVIEIK LIKGPKGLGF SIAGGVGNQH
     IPGDNSIYVT KIIDGGAAQK DGRLQVGDRL LMVNNYTLEE VTHEEAVAIL KNTSDVVYLK
     VGKPTSVYLT DPYGPPDITH PFSPAMENHI SSPGNNGTLE YKSSLPPISP GRYSPIPKHL
     LGEEDINRNS SLDEGESHRF DSQHFQLREP RKIVLHKGST GLGFNIVGGE DGEGIFVSFI
     LAGGPADLSG ELRRGDQILS VNGIDLRGAT HEQAAAALKG AGQTVTIVAQ YRPEEYGRFE
     AKIHDLREQM MNHSMSSGSG SLRTNQKRSL YVRALFDYEK AKDSGLPSQG LSFRYGDILH
     VINASDDEWW QARRVTPDGD SEEMGVIPSK RRVERKERAR LKTVKFNSKL GTLDSKPSFN
     DKRKKNFIFS RKFPFYKNKE MGEQDASDSE RSQEDLILSY EPVIRQEINY ARPVIILGPM
     KDRINDDLIS EFPDKFGSCV PHTTRAKREY EVDGRDYHFV TSREQMEKDI QEHKFIEAGQ
     YNDNLYGTSV QSVKYVAERG KHCILDVSGN AIKRLQVAQL YPIAIFIKPK SIESLMEMNK
     RLTEEQAKKT YDRAMKLEQE FGEYFTALVQ GDTLEDIYNH CKLVIEEQSG PYIWIPSKEK
     L
//