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Database: UniProt
Entry: A0A3B3RQ18_9TELE
LinkDB: A0A3B3RQ18_9TELE
Original site: A0A3B3RQ18_9TELE 
ID   A0A3B3RQ18_9TELE        Unreviewed;      1184 AA.
AC   A0A3B3RQ18;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000934};
DE            EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000934};
GN   Name=PTPN14 {ECO:0000313|Ensembl:ENSPKIP00000020604.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000020604.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000020604.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000934};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC       ECO:0000256|PIRNR:PIRNR000934}.
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DR   AlphaFoldDB; A0A3B3RQ18; -.
DR   STRING; 1676925.ENSPKIP00000020604; -.
DR   Ensembl; ENSPKIT00000001222.1; ENSPKIP00000020604.1; ENSPKIG00000005280.1.
DR   GeneTree; ENSGT00940000156874; -.
DR   OrthoDB; 3108587at2759; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR   CDD; cd17191; FERM_F1_PTPN14; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR014392; PTP_non-rcpt_14/21.
DR   InterPro; IPR041782; PTPN14/21_FERM_C.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000934};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR000934}; Hydrolase {ECO:0000256|PIRNR:PIRNR000934};
KW   Protein phosphatase {ECO:0000256|PIRNR:PIRNR000934}.
FT   DOMAIN          20..305
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          906..1177
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1087..1168
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          658..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          702..722
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..721
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1118
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ   SEQUENCE   1184 AA;  134630 MW;  5587E32AFDF2454A CRC64;
     MPFRIRLGRH RRYVLSKNCF VTRIRLLDNN VIECTLSVES TGQECLEAVA QRLELRETHY
     FGLWFHGKSQ LQRWVELEKP LKKQLDKYGN EPLLFFGVMF YVPNVSRLEQ EVTRYQYYLQ
     VKKEVLDGRL QCTVEQGVRL AGLAVQADFG DYTQFQSQDF LREYVLFPVN WPHVEEVLEE
     WTQKVAEEHK SHCRMQPAEA ELLYIKEVEK LDGFGQESFA AKDNYTNDIY IGVSFIGVFV
     KHRNGRSIMQ HRWKDIGNIA HNKSAITVEI TSRDDTIMFH TEDMEMAKYI SRLFTARHKF
     YKQNKICTEP ARSPVPIRRR PTWAGSSLPR PRSCILQTMH SKYGEPFQDT QSSQDSIFHD
     DLYYKSETSL DRCTADFFRN GSVPNGSVYS TSSMNSLNHS QNFIQASPMS SNLSIPGSDV
     MRPDYIPSHR HSAIIAPSYR PTPEYEAVMR KRHMVPPDCH SQSLRNLNIS NTFAYRQPEA
     LVYSQPEMRE RAQYHGPYNP HVSYSRPTAP SAHISPGCGP ATCHPPGSAI SHTVSTPELA
     NTKQQGTQGY STTHMLKNHL SRPPPPYPSF RPATSTPDLA SHRHRCMGGS SPELVTRKVQ
     LSVKTFKPDS SAVVHQSLQE VSEPLTASKH HSALSKRPSL EVISSMVRGM EAMAMKTLNA
     PLPRRNTLRE PPEMPAQKPA EAPAAAPYQH KKTLSNATML IHSSESEEDE EEEEEEESPD
     LDVQIPALNE DISVQLQAAL AKMPNKPPPD YPGPRKSVSN SVIRPERGHE CGPAPEDEEE
     DSQSQSGTLT RTEPAGLNGS VLGPSISEPD LTSVKERVRK EPVKERPVSE MFSLEDSIVE
     SEIRLRTLEK QKMSADSLKR PLMMAALNGL YVARMPVPEN QPEDLSKSST DELCKVLERK
     VQEERVFTEY EQIPKKKAEC AVTTATLPEN VERNRFRDVV PYEENRLELV PTKENNTGYI
     NASHIKVMIS GEEWHYIATQ GPLPNTCQDF WQMVWEQGVN VIAMVTAEEE GGRCKSHRYW
     PKLGSKHNSA THGKFKVTTK FRTDSGCYAT TGLKVKHLLS GQERTVWHLQ YTDWPEQGCP
     EYVQGFLSYL EEIQSVRRHT NSMLDTSRSL NPPIVVHCSA GVGRTGVVIL TELMISCVEH
     NQKVDIPGML GRLRQQRMLM VQTISQYKFV YQVLIQFLKN SRLI
//
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