ID A0A3B3RQ18_9TELE Unreviewed; 1184 AA.
AC A0A3B3RQ18;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000934};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000934};
GN Name=PTPN14 {ECO:0000313|Ensembl:ENSPKIP00000020604.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000020604.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000020604.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR000934};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC ECO:0000256|PIRNR:PIRNR000934}.
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DR AlphaFoldDB; A0A3B3RQ18; -.
DR STRING; 1676925.ENSPKIP00000020604; -.
DR Ensembl; ENSPKIT00000001222.1; ENSPKIP00000020604.1; ENSPKIG00000005280.1.
DR GeneTree; ENSGT00940000156874; -.
DR OrthoDB; 3108587at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17191; FERM_F1_PTPN14; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000934};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR000934}; Hydrolase {ECO:0000256|PIRNR:PIRNR000934};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR000934}.
FT DOMAIN 20..305
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 906..1177
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1087..1168
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 658..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..721
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1118
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1184 AA; 134630 MW; 5587E32AFDF2454A CRC64;
MPFRIRLGRH RRYVLSKNCF VTRIRLLDNN VIECTLSVES TGQECLEAVA QRLELRETHY
FGLWFHGKSQ LQRWVELEKP LKKQLDKYGN EPLLFFGVMF YVPNVSRLEQ EVTRYQYYLQ
VKKEVLDGRL QCTVEQGVRL AGLAVQADFG DYTQFQSQDF LREYVLFPVN WPHVEEVLEE
WTQKVAEEHK SHCRMQPAEA ELLYIKEVEK LDGFGQESFA AKDNYTNDIY IGVSFIGVFV
KHRNGRSIMQ HRWKDIGNIA HNKSAITVEI TSRDDTIMFH TEDMEMAKYI SRLFTARHKF
YKQNKICTEP ARSPVPIRRR PTWAGSSLPR PRSCILQTMH SKYGEPFQDT QSSQDSIFHD
DLYYKSETSL DRCTADFFRN GSVPNGSVYS TSSMNSLNHS QNFIQASPMS SNLSIPGSDV
MRPDYIPSHR HSAIIAPSYR PTPEYEAVMR KRHMVPPDCH SQSLRNLNIS NTFAYRQPEA
LVYSQPEMRE RAQYHGPYNP HVSYSRPTAP SAHISPGCGP ATCHPPGSAI SHTVSTPELA
NTKQQGTQGY STTHMLKNHL SRPPPPYPSF RPATSTPDLA SHRHRCMGGS SPELVTRKVQ
LSVKTFKPDS SAVVHQSLQE VSEPLTASKH HSALSKRPSL EVISSMVRGM EAMAMKTLNA
PLPRRNTLRE PPEMPAQKPA EAPAAAPYQH KKTLSNATML IHSSESEEDE EEEEEEESPD
LDVQIPALNE DISVQLQAAL AKMPNKPPPD YPGPRKSVSN SVIRPERGHE CGPAPEDEEE
DSQSQSGTLT RTEPAGLNGS VLGPSISEPD LTSVKERVRK EPVKERPVSE MFSLEDSIVE
SEIRLRTLEK QKMSADSLKR PLMMAALNGL YVARMPVPEN QPEDLSKSST DELCKVLERK
VQEERVFTEY EQIPKKKAEC AVTTATLPEN VERNRFRDVV PYEENRLELV PTKENNTGYI
NASHIKVMIS GEEWHYIATQ GPLPNTCQDF WQMVWEQGVN VIAMVTAEEE GGRCKSHRYW
PKLGSKHNSA THGKFKVTTK FRTDSGCYAT TGLKVKHLLS GQERTVWHLQ YTDWPEQGCP
EYVQGFLSYL EEIQSVRRHT NSMLDTSRSL NPPIVVHCSA GVGRTGVVIL TELMISCVEH
NQKVDIPGML GRLRQQRMLM VQTISQYKFV YQVLIQFLKN SRLI
//