ID A0A3B3RU54_9TELE Unreviewed; 1496 AA.
AC A0A3B3RU54;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|Ensembl:ENSPKIP00000021848.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000021848.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000021848.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR STRING; 1676925.ENSPKIP00000021848; -.
DR Ensembl; ENSPKIT00000002492.1; ENSPKIP00000021848.1; ENSPKIG00000006054.1.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14628; R-PTP-D-2; 1.
DR CDD; cd14624; R-PTPc-D-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045905; R-PTP-delta_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 851..874
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..118
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 130..219
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 227..309
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 316..406
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 411..507
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 509..602
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 604..690
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 941..1196
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1116..1187
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1228..1487
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1405..1478
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 882..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1496 AA; 168760 MW; 805DDB9B0D62F2A3 CRC64;
EHDHWTPSVT TLITMILICI IVETASPPKF LRTPNDQTGV QGGVASFICQ ATGDPRPKIV
WNKKGKKVSN QRFEVIEFDD GSGSVLRIQP LRTPRDEAIY ECVATNSVGE TSASTRLTVL
REDQLPPGFP TIDMGPQLKV VERTRTATML CAASGNPDPD ISWFKDFLPV NTTNNNGRIK
QLRSGALQIE QSEESDQGKY ECVATNSDGT RYSAPANLYV RVRRVPPRFS IPPTDNEIMP
GGSVNITCVA VGSPMPYVKW MLGAEDLTPE DDMPIGRNVL ELTDVRQSAN YTCVAMSTLG
VIEAVAQITV KALPKPPGMP VVTERTATSI TLTWDSGNPE PVSYYIIQHR SKLSEDTYKE
IDGVATTRYS VGGLSPYSDY EFRVVAVNNI GRGPPSEPIE ARTAEQAPST APRQVRGRML
SSTTAIIHWD EPEEANGQIM GYRVYYTTEP TLHVNYWEKQ MVRGANFLTV QGLTPNKTYY
IRVLAFTSVG DGPLSPDLQI VAKTGVPSQP TDFKAEAKSE TSILLSWIPP TQNGQDNQII
GYELIYKKGD DKEEKRISFE PTITYLLKDL KPFSTYTFLL AARSKLGIGA YTNEISAETP
QTLFAKNFHV KAAMKTSVLL TWEIPESYNP AQPFTILYDN GQSVEVDGKL TQKLITNLQP
ETQYSFLLTN RGNSAGGLQH RVSTMTAPDV LRTKPYLVSK TNSDGMVTVE LPSVQTTEKV
RGYYIVMVPL KKQRTGKFLK PWDSPDDMNL DELLKEINRT SRSLRFRREL EPKAYIAAYF
KELPSEFTLG DAKMYGDFEN KPLQSGQEYI FFVLAVLEMS DHTMYATSPY SDPVVSADND
PQPIIDEEEG LIWVVGPVLA VVFIICIVIA ILLYKRKRAE SDGRKGSLPS SKELPSHHPT
DPVELRRLNF QTPGMASHPP IPIMELADHL ERLKANDNLK FSQEYESVDP GQQFTWEHSN
LEVNKPKNRY ANVIAYDHSR VLLSAIEGIP GSDYINSNYI DGYRRQNAYI ATQGALPETF
GDFWRMIWEQ RSASIVMMTK LEERSRVKCD QYWPTRGTET YGLIQVTLLD TVELAAYCVR
TFALYKNGSS EKREVRHFQF TAWPDHGVPE HPTPFLAFLR RVKACNPPDA GPMVVHCSAG
VGRTGCFIVI DAMLERIKHE KTVDIYGHVT LMRAQRNYMV QTEDQYVFIH DALQEAVTCG
NTEVPARNLY AYIQKLTQIE SGENVTGMEL EFKRLANTKA HTSRFISANL PCNKFKNRLV
NIMPYESTRV CLQPIRGVEG SDYINASFID GYRQQKAYIA TQGPLAETTE DFWRMLWEHN
STIVVMLTKL REMGREKCHQ YWPAERSARY QYFVVDPMAE YNMPQYILRE FKVTDARDGQ
SRTVRQFQFT DWPEQGVPKS GEGFIDFIGQ VHKTKEQFGQ DGPISVHCSA GVGRTGVFIT
LSIVLERMRY EGVVDIFQTV KMLRTQRPAM VQTEDQYQFC YRAGLEYLGS FDHYAT
//
