ID A0A3B3RZA0_9TELE Unreviewed; 1240 AA.
AC A0A3B3RZA0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ras protein specific guanine nucleotide releasing factor 2 {ECO:0000313|Ensembl:ENSPKIP00000023116.1};
GN Name=RASGRF2 {ECO:0000313|Ensembl:ENSPKIP00000023116.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000023116.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000023116.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3RZA0; -.
DR STRING; 1676925.ENSPKIP00000023116; -.
DR Ensembl; ENSPKIT00000003793.1; ENSPKIP00000023116.1; ENSPKIG00000006766.1.
DR GeneTree; ENSGT00940000155679; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF187; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 239..425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 466..586
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 633..747
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1005..1237
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 707..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..184
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 755..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 141190 MW; 379B36BC3516E387 CRC64;
MQKSVRYNEG HALYLSVLAR KEGTKRGYLC KKTTDNSRWH DKYFALHQNL LFYFENDQST
RPSGIYLLEG CTCERVPAPK VSAIGKETLD KQYYFLVMFG HDGQKPLELR TEEELDCDDW
VDAIQQASYS DIIIEREVLM QKYIHLVQIV ETEKVAANQL RHQLEDQDTE IERLKAEIVA
LNKTKERMKP YQVNQEEDDP DIKKIKKVQS FMRGWLCRRK WKIIVQDYIC SPHAESMRKR
NQIVFNMVEA ETEYVLQLSI LVNCFLRPLR MAASSKKPPI SHDDVSSIFL NSETIMFLHE
IFHQGLKARI ANWPTLVLAD LFDILLPMLN IYQEFVRNHQ YSLQVLANCK QNRDFDKLLK
QYEANAACES RMLETFLTYP MFQIPRYIIT LHELLAHTPH DHVERMSLEF AKSKLEELSR
VMHDEVSDTE NIRKNLAIER MIVEGCDILL DTSQTFVRQG SLIQLPSVER GKLSKVRLGS
LTQKKEAERQ CFLFTKHFLI CTRSSGGKLH LLKQGGALSL IDCTLIEEPD ASDEERESNS
TGQVFCHLEF KIVVETPDGL AFTVVLLAPS RQEKAAWTSD ISQCIDNIRC NGLMTSVFEE
NSKVPVPHMI RSDARLHKDD VDICFSKTLN SCKVPQIRYA SVERLLERLT DLRFLSIDFL
NTFLHTYRIF TAAAVVMDKL ADIYKKPFTS IPVRSLELFF ATSQSGRSGE LQNDKSPHLC
RKFSSPPPLS IPPRAVSPVH ARKLSLSSPV GAKTGALDLS TSTPASSASS PTSAQPSDTS
SPPAGTKVPL DLSRGPPSPE HGPVTLEEGG EVPRIDALNI LTFLTAVLES VSMDKFIPET
PPVNEPGDMS PCRSPSTPRH LARYRQPGVQ SAESPRFSVS PTSAFAIATA AAGHSSPPGF
TNSERTCDKD FIIRRAATNR VLNVLRHWVS KHSQDFEMNC DLKMSVICLL EEVLRDPDLL
PQERKATANI LSVLSQDDQE DTQLRIEDIL QIAESPKTEC FESLSAMELA EQITLLDHIV
FRSIPYEEFF GQGWMKVDKT ERTPYIMKTS QHFNEMSNLV ASQIMTHTDV GSRANSIEKW
VAVADICRCL HNYNGVLEIT SALNRSAIYR LKKTWAKVCK QTKALMDKLQ KIVSSEGRFK
NLRETLKNCN PPCVPYLGMY LTDLAFIEEG TPNFTEEGLV NFSKMRMISH IIREIRQFQQ
TPYRIEHQPK VTQYLLDKTL VMDEDTLYDL SLKIEPRLPA
//
