ID A0A3B3S289_9TELE Unreviewed; 1062 AA.
AC A0A3B3S289;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000256|PIRNR:PIRNR000631};
DE EC=2.7.10.1 {ECO:0000256|PIRNR:PIRNR000631};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000024847.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000024847.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor tyrosine-protein kinase involved in numerous
CC cellular mechanisms including cell proliferation, neuronal navigation,
CC cell migration, and cell differentiation upon binding with glial cell
CC derived neurotrophic factor family ligands.
CC {ECO:0000256|PIRNR:PIRNR000631}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|PIRNR:PIRNR000631};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR000631}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000256|PIRNR:PIRNR000631}.
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DR AlphaFoldDB; A0A3B3S289; -.
DR Ensembl; ENSPKIT00000005568.1; ENSPKIP00000024847.1; ENSPKIG00000007875.1.
DR GeneTree; ENSGT00940000158499; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd11304; Cadherin_repeat; 1.
DR CDD; cd05045; PTKc_RET; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041163; Ret_CLD1.
DR InterPro; IPR040667; Ret_CLD3.
DR InterPro; IPR041317; RET_CLD4.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016249; Tyr_kinase_Ret_rcpt.
DR PANTHER; PTHR24416:SF485; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF17756; RET_CLD1; 1.
DR Pfam; PF17812; RET_CLD3; 2.
DR Pfam; PF17813; RET_CLD4; 1.
DR PIRSF; PIRSF000631; TyrPK_receptor_Ret; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50268; CADHERIN_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000631};
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|PIRNR:PIRNR000631};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR000631};
KW Kinase {ECO:0000256|PIRNR:PIRNR000631};
KW Membrane {ECO:0000256|PIRNR:PIRNR000631};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000631, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Transferase {ECO:0000256|PIRNR:PIRNR000631};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000631}.
FT DOMAIN 177..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 672..964
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 822
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000631-1"
FT BINDING 706
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1062 AA; 120545 MW; 980E12A63AA627DC CRC64;
MGFPGLMQDR GRDYFESMYV GQETGSALLQ LHGLRETDTE RPHFYLCPNS PMNKDPYKSW
FHLDERTGIL SLNKTLDSSD FKLSIKSHAS SLTMSLKRLS LKATVTLEPQ QNLSCFWSPT
VNIILTFINT APPCDHQNLI KMCFPEKDAS PHIKENRWSG PFRQLRRLTY QDLCPNFTIT
YSLEAGIPSC IISLVVTRSL DREEKEVHEL LLVCTVTTES KVHKMSMPIL VNVYDEDDSA
PYVNGTDTED VRIEFNRMEV SWSLVLSSCP PSMRTNDSWI KEMFSVEHSF IEEKAIFGNV
RGTIHKYRLA LNKNIPVPEK RSFLLDYLVN DTTFPGSEGT VMLHFNVTIL PVSIRFTNPL
YHFPVSRRSS PYAQIGRICI DNCLKFQGIN ITYRLAMADD NVSSVERVCH SIVSIAQSLT
DIWGVLYVNH TEGLWQPQCQ SLQYMVVAKE QLSQLQAEAR LRVEFYDKEK QSLERDCPLS
CAKQRRRGPC EACSGLGATT GRWVISMNYS TCSPDLSTCP DGYCDIVESK DLAICPQDCT
DKPIVGGHER GLLYGIKAGH GTCYCADNCF CEMDNSMCDD VCKTVVATAL LLSFIISVLL
STYFINRYHK SSPKSPKPSA EMSFRRPAQA YPISFSANNV RRPSLESMEN QVAIDTFKIP
EDPKWEFPRK NLVLGKTLGE GEFGKVVKGT AFRLKGKAGY TTVAVKMLKE NASQSELRDL
LSEFTLLKQV NHPHVIKMYG ACSQDGPLYL IVEYAKYGSL RNFLRDSRKV GSSYMGGDGN
RNSSYLENPD ERALTMGDLI SFAWQTSRGM AYLAEMKLVH RDLAARNVLV AEGRKMKISD
FGLSRDVYEE DSYVKRSKGR IPVKWMAIES LFDHIYTTQS DVWSFGVLLW EIVTLGGNPY
PGIAPERLFN LLKMGYRMER PENCTEEMYS LMLRCWKQEP DKRPTFSEIS KELEKMMVKS
RDYLDLAAST PADALLYDDA LSEEDTPLVD CNNSPLPRTL PSTWIENKLY GMSYPNWPEK
SPVLLTRLDG TNPVFTRYAN DSVYANWMVS PSTAKFMDKF DS
//
