ID A0A3B3S3U6_9TELE Unreviewed; 962 AA.
AC A0A3B3S3U6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Sodium/calcium exchanger 2-like {ECO:0000313|Ensembl:ENSPKIP00000025193.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000025193.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000025193.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3B3S3U6; -.
DR STRING; 1676925.ENSPKIP00000025193; -.
DR Ensembl; ENSPKIT00000005919.1; ENSPKIP00000025193.1; ENSPKIG00000008069.1.
DR GeneTree; ENSGT00940000158344; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF8; SODIUM_CALCIUM EXCHANGER 2; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..962
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017418958"
FT TRANSMEM 89..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 937..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 424..524
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 554..654
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 962 AA; 106665 MW; 722825DF84CB710B CRC64;
MFAVPRRTMG SHLRLFLPGV LLLLFLLPQP CSPESQPIEV EPVSPSVTTE LYGNDSDEAK
RPCSDLTVCS PGILLPVWLP LQPGLGDQVA RAIVYFVSLM YMFLGVSIIA DRFMASIEVI
TSQEKEVTIT MPNGETSVAT VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHKFEAGEL
GPGTIVGSAA FNMFVIIGLC VWVIPAGESR KIKHLRVFFI TAFWSIFAYI WLYLILAVMS
PGIVEVWEAL VTLLFFPVCV ILAWIADRRL LFYKYMHKRY RADKRRGIVV ETEGEMTPKG
DEMMMDGKFP ARAGILPTEN CQDGNSVVGA GLPNSNSTTV AMDNSKDLDE SRKEVIRILK
ELKQKYPDKE LEQLVELANY YALMHQQKSR AFYRIQATRM MIGAGNVLKK HAADNARRAA
ATEDPAEKDD LETCSHITFE SPQWQCMENC GTVALAVVCQ GGTGESTFYV DYRTEDGSAN
AGSDYEYSEG TLVFKPGETR KEIKVGIIDD DIFEEDEHFF VRLLNLRVGD AEGMFESEGV
GMAPKGRLVE PLVATVTILD DDHAGIFTFG ERLVRVSESV GTMEVTVVRN SGARGTVIIP
YHTEPGSAHG GGVDYEDAQG ELEFTNDQTT QTLKIRIVDD EEYEKHENFF IVLEEPRWLK
RGISALLLNQ VDQEAELSAE EIEARRIAEM GKPVLGEHGR LEVVIEESYE FKSTVDKLIK
KTNLAVVIGT HSWREQFVEA VTVSAGDGEE DEEGREERRP SCFDYIMHFL TVFWKVLFAC
VPPTEYWNGW ACFIVSISVI GFLTAVIGDL ASHFGCTIGL RDTVTAVVFV ALGTSIPDTF
ASKVAAIQDQ YADASVGNVT GSNAVNVFLG IGVAWSVAAV YWHVQGKPFR VDPGSLAFSV
TLFTIFAFIS FGVLLLRRRP SVGGELGGPR LPRFFTSLLF FGLWFLYILF SSLEAYCHIK
GF
//
