ID A0A3B3S458_9TELE Unreviewed; 1628 AA.
AC A0A3B3S458;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 2b {ECO:0000313|Ensembl:ENSPKIP00000025477.1};
GN Name=IQSEC2 {ECO:0000313|Ensembl:ENSPKIP00000025477.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000025477.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000025477.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR STRING; 1676925.ENSPKIP00000025477; -.
DR Ensembl; ENSPKIT00000006213.1; ENSPKIP00000025477.1; ENSPKIG00000008307.1.
DR GeneTree; ENSGT00940000159667; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
FT DOMAIN 743..936
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 46..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..651
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1295
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1378
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1481
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1628 AA; 177246 MW; F780FBCA45C2762C CRC64;
METGQGSPES PNRAVEYLLE LNNIIESQQK LLETQRRRIE ELEVQLDRVN QENKDLRLDR
RPRMPDVSGS AQPGSDAALP TNSHGDSAPP PPLPARERRG HARLTRGLSC GSAPVERGRP
NRPDCSGAGH AKTLQRQLSS NSTPCNLTAT KASATTASSL LHPNLTANSH CRHHHCSHSR
PRLSRSARSP PSAKHTEQAS VDTEPQRTES GSFSDSACSQ AAYPRSSERR GDAPRGPTVA
ATSPVSLAWS QRTRHQPASL ALRKQEEEEN KRCKTLSDSY ELSTDLQDKK VEMLERKYGG
YFLSRRAART IQTAFRQYRM NKNFERLRSS ASESRMTRRI ILSNMRMQYS FDERQPVTQQ
QHYPHGAGPP SPPQHGRSRS PPTGPERDSG SPPRLQGNRS GEYTHLDDSF NKQVKSLADS
IDDTLTCRPG RDDSQEGSRE GEGIGGVEGD DFGECVWSNS SNPLSRRGHS ERERGGGGGL
SMHEDSTATS YSDVTLYMDD GLPSSPLSLD RAPSSTDTEY WGMGGGVGIR EDSRDTEGGG
SSNSRRSTPC TECRDYRLRG AHLPLLTIEP PSDSSVDMSD RSDRGSLGRQ LVYEQEPSGS
PQGTLKHGTS ARSMVAAQGQ TRAAGRPHPS IPSQVPHHPH HHHHHHPHHH HQYPDTPSSS
SSPQQPPATP LSSSSSAPVP AGSLEQPCCS DGDNDSLNST TNSNETINCS SGSSSRDSLR
EPLPPLGKQT YQRESRHSWD SPAFDNDVVQ RRQYRIGLNL FNKKPEKGIQ YLIERGFVSD
TPVGIARFIL ERKGLSRQMI GEFLGNRQKQ FNKDVLDCVV DEMDFSGMDL DDALRKFQAQ
IRVQGEAQKV ERLVEAFSQR YCVCNPAVVR QFQNPDTIFI LAFAIILLNT DMYSPNVKPE
RKMKLEDFIK NLRGVDNGQD IPRDLLVGIY QRIQKWELRT NDDHVSQVQA VERLIVGKKP
VLSLPHRRLV CCCQLYEVPD PNRPQRTGVH QREVFLFNDL LVVTKIFQKK KNSVTYSFRQ
SFALVEMQVH MFQNSYYPHG IRLTSAIPGG ERKVLIVFTA PSQQDRTRFT TDLRESVAEV
QEMEKYRVES ELEKQKGVMR PSLLTGGVLA GGGTVGGGVK SEVVNGSLGR PSLDDTYSTG
EGLKRTALSS SLRDLSETGK RGRRNSVGSL DSTIEGSIIS SPRPHQRLPM ATMVSGCYGL
EDYRSHRPIL SPGSGVGGGP GQQHNAAGTV GTGGGGPVSS SVEKGGMGNA TGGGSGSFLG
SLFGSKRGKA PGPIIPPGPH YPAPVPPPTS GGPPPLSPSS LCQSDGGPSK IQALHAQYCH
TGAGQPPPPY QHHHRYSVQT VPLPSQAASA PVANHHTLQR GSLPRRPPPA PSHAPPPPVS
QHAMQGRYTG MALAGGCPVP LSPHSLHSPL PPYTLYHAQH TPSVRGGAPP GKPPLTLAHS
QPHTHSHVHP GHAPHPSSHP VPPPHFVFGA PAQPPPGPIT ARLLPQGAQY LPQYPPLSSI
PPPPPPPPPP PPPPFPPPFL PPYPSYASLP SPPPAPWPAT AGSWSTGGSG GRGPGQRHRY
RGELQIQARQ SDQHRGLRDS LVWGRGTPGG TLRANSGDRA VVDQGGGASR KKRSFLRLCY
FHLRFPHM
//
