ID A0A3B3S5E3_9TELE Unreviewed; 714 AA.
AC A0A3B3S5E3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000025241.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000025241.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B3S5E3; -.
DR Ensembl; ENSPKIT00000005969.1; ENSPKIP00000025241.1; ENSPKIG00000008175.1.
DR GeneTree; ENSGT00940000159781; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF25; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..714
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017401952"
FT TRANSMEM 546..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 178..222
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 289..327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 329..365
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 367..404
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 482..518
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 180..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 193..205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 213..222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 317..326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 355..364
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 394..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 432..441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 470..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 508..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 714 AA; 78378 MW; 2FB0C7804C20C530 CRC64;
MGRQPLMIAA ILCALMCQAF GSGVFELKLQ EFLNKKGVMG NTNCCKGGTA SGFQQCECKT
FFRICLKHYQ ANVSPEPPCT YGGAVTPVLG SNSFQVPETT SDNFFTNPVR FPFGFTWPGT
FSLIIEALHT DSSEDLSTEN PERLISRITT QRHLTVGEEW SQDLQTGGRT ELKYSYRFIC
DEHYYGDGCS VFCRPRDDAF GHFTCGERGE IVCNAGWKGH YCTDPICLPG CDEEHGFCDK
PGECKCRVGF SGRYCDDCIR YPGCLHGTCQ QPWQCNCQEG WGGLFCNQDL NYCTHHKPCM
NGATCTNTGQ GSYTCSCRPG FTGASCEIEV NECSNNPCRN GGSCTDLENT YSCVCPPGFY
GTNCDLSAVT CADGPCFNDG RCVDNPDGGY FCQCPAGYSG FNCEKKIEPC SSSPCTNGAQ
CMDHGTSYLC QCLEGFVGKN CDDSINMCSS YPCQNGGTCQ DGIDDYTCTC PPGYVGKNCS
QPVSWCEHNP CHNGATCHER DGRYVCACFQ GYGGKNCQFL LPEHSGSQPD VKAPGKRYSE
AGELPWTAVC AGIILVLLLL LGGAVLAVYF RVKGQRQGQL ADGHSESETM NNLTHNRHHE
KDLSVSVVSS TQIKNTNKKV DFRCDNGSAE RNSYKARNPA MDYNLVYELK HEELPIVPGN
HGRGDCELQE KHCKRLKSDA SEIKQPESAC KDTKYQSVYV ISEEKDECII ATEV
//