ID A0A3B3S7C1_9TELE Unreviewed; 798 AA.
AC A0A3B3S7C1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Guanine nucleotide exchange factor VAV3-like {ECO:0000313|Ensembl:ENSPKIP00000026669.1};
GN Name=VAV3 {ECO:0000313|Ensembl:ENSPKIP00000026669.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000026669.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000026669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3S7C1; -.
DR STRING; 1676925.ENSPKIP00000026669; -.
DR Ensembl; ENSPKIT00000007427.1; ENSPKIP00000026669.1; ENSPKIG00000009048.1.
DR GeneTree; ENSGT00940000155252; -.
DR OrthoDB; 2911406at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd21264; CH_VAV3; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003096; SM22_calponin.
DR PANTHER; PTHR45818:SF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..124
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 197..376
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 405..506
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 517..566
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 592..658
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 670..764
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 572..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 91940 MW; 52476ADD7EE7192F CRC64;
MGSGTMEHWR QCAHWLIGCN VLPPNHRVTW ESAQVFDLAQ TLRDGVLLCQ LLNNLRAQSI
NLKEINLRPQ MSQFLCLKNI RTFLAACTDV FGMKKSELFE AFDLFDVRDF GKVMDTLSRL
SHTAIAQQMG IRPFPTEDSM DDDDIYSHLE DLIDENGVED EEDLYDYVYD DDEGGEVYED
LMKAEAVPPP KQAETDIRGC CLTEIKQTEE KYTETLESIE KFFMTPLRKF LSTGEVEKVF
VNIPDLVKVH KCLMVEVQDS VVNKNAQNLY QIFVAYKERL LIYGKYCSHV EPAIATLDNI
SKDREDVRLK LEECSKRANS GKFTLRDLLV VPMQRVLKYH LLLQELVKHT HDPTEKGNLR
TALDAMKDLA QYVNEVKRDN ETLREIDQYQ RSIENLNQSL RNYGRPKGDG EVRVLSVDKR
AKQDRHIFLF DMAVIVCKRR GDNYEMKEVI DLHSFKISNP AMDKENKKWS YGFYLTHLHG
QNGFEFFFKT KEMKKKWLEQ FSMAISNIHP ENGNSNLHEF RMHTFDRITY CGSCRMLLRG
IFNQGYRCAK CGVGAHKECL GRLETCGNAN TAQDAGTQRH QKRTDHRRQQ DSGLPKMLVI
RAYHGVPSPS CGPPLSIEPG EVVELMGADP HSAWWQGKIL STREVGFFPS DAVKPCPCVP
KPVDYSSQPW FAGPMERPQA EAELGNRGNS TYLVRHRTKE STEYAISIKY NHDVKHIKIL
ARDGFFHIAE NKKFRSILEL IEYYKHHSLK EGFRSLDTVL LYPYKNPESG ATHRSGRAGM
NGEYRRNAGH DQPCEQQQ
//
