ID A0A3B3S7L0_9TELE Unreviewed; 352 AA.
AC A0A3B3S7L0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Diencephalon/mesencephalon homeobox 1 {ECO:0000313|Ensembl:ENSPKIP00000025976.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000025976.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000025976.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR AlphaFoldDB; A0A3B3S7L0; -.
DR Ensembl; ENSPKIT00000006724.1; ENSPKIP00000025976.1; ENSPKIG00000008622.1.
DR GeneTree; ENSGT00940000155505; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR46639; DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR PANTHER; PTHR46639:SF2; DIENCEPHALON_MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 64..124
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 329..342
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 66..125
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 123..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 38901 MW; 658417EC6D1C3EAC CRC64;
MQHYGVNGYS LHAMNSLSAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL ADIILEARYG
SQHRKQRRSR TAFTAQQLEA LEKTFQKTHY PDVVMRERLA MCTNLPEARV QVWFKNRRAK
FRKKQRSLQK EQLQKQKEVT EGALEEVKGE PPAAKGPPHP LPAELSVEVN VTSAEQSGSE
SATEDNTDKE EEPKGDKGLL PGHKSPPCKR LSPKADSPLG SPAIPCSSGI NGGIAQNHSY
SSSPLSLFRL QEQFRQHMAA TNNLVHYSSF DMGTPSSVPY LGMNVNMPAP LGSLPCQPYY
QSLSHAQQVW NNPLLQASGG LPSLNSKTTS IENLRLRAKQ HAASLGLDTL PN
//
