ID A0A3B3S8I2_9TELE Unreviewed; 784 AA.
AC A0A3B3S8I2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Major facilitator superfamily domain containing 6 {ECO:0000313|Ensembl:ENSPKIP00000026321.1};
GN Name=MFSD6 {ECO:0000313|Ensembl:ENSPKIP00000026321.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000026321.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000026321.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR AlphaFoldDB; A0A3B3S8I2; -.
DR STRING; 1676925.ENSPKIP00000026321; -.
DR Ensembl; ENSPKIT00000007075.1; ENSPKIP00000026321.1; ENSPKIG00000008847.1.
DR GeneTree; ENSGT00530000063599; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF2; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..539
FT /note="Major facilitator superfamily associated"
FT /evidence="ECO:0000259|Pfam:PF12832"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 86246 MW; 73D2773DC3408C5F CRC64;
MASDDRTGIL MDDETDQRWN DTLDELDNTE PAEEKPRTSS PVPAPESPQS DAATTSSQPG
VGTVGSTFGQ VNKHLLVSKI FYFFFYAAYG SLHPLLPIYF KQLGMTASRS GLLVGIRYFI
EFCSAPFWGV IADRFKKGKA VLLFSVLCFL LFNGGIGFVK PAEMHCVEKS PPEASNNSAQ
ANTTQVTSTT QPMGDNSTHV STPQNATSSG FTTEQFTATT VASNTHELIY DEGQVKTIFL
TILLVIIIGE FFSAPAVTIV DTVTLQYLGR HRDRYGLQRM WGALGWGLAM LCVGISIDHM
QLLVLIQDCG LFHLKDFLIT FVVFGVLAGL ALLVATQFSF DSSGSAVSRG VYDSASPGAI
VAEGQREFHF SDLLRVLCSV RYSTVLFVAW FMGFGYGFVF SFLYWYLQTL NGTTTLFGIC
SVLSHVSELV AYFTSHKLIK LVGHIRVLYL GLACNTARYL YISYLENAWT VLPMEVLQGM
THALVWAACI SYLSATVPLA LRTSTQGVLQ GLHLGLGRGC GAMVGGVFVS YFGEAATFRG
LGMASLIILI LFSFIQFLMG QDDSGGMAMA SSGSVSIATI NLTREPQTLQ PEPPRKRKHQ
EEQEDRDMPP WAFTVSPWVT MAFTIFHVLE TIKMAKRRAL VDTQDPQVSG AASLRIWLRR
GVDYSFLFGD NLRHYSCYST EMCWHDLRVA SLCQQVTNDT TAPVSPPVDM PAAQPSTSQQ
LEPSNKPVRR PSKKLKERTD SDGTERPPST APPVGSNSTV DNHFPLPGNF DLPPHRSSNN
PFYQ
//