ID A0A3B3SAJ0_9TELE Unreviewed; 1162 AA.
AC A0A3B3SAJ0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1 {ECO:0000313|Ensembl:ENSPKIP00000027021.1};
GN Name=RASGRF1 {ECO:0000313|Ensembl:ENSPKIP00000027021.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000027021.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000027021.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3SAJ0; -.
DR Ensembl; ENSPKIT00000007784.1; ENSPKIP00000027021.1; ENSPKIG00000009181.1.
DR GeneTree; ENSGT00940000157599; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 240..426
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 456..586
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 633..748
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 949..1162
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 710..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 800..814
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 133075 MW; A38D2FA201A5C46D CRC64;
MQKGVRLNDG HVTYLGLLAK KDGTRRGCLS KKSSDNTKWH TKWFALLQNM LFYFENESSS
RPSGLYLLEG CVCDRAPSPK PSLTAKECLE KQYYFTISFN HESQKPLELR TEDAKDCDEW
VAAITHASYR NLATEHEALM QKYLHLLQIV DTEKTVAKQL RQQIEDGEIE IERLKSEIAG
LLKDNEKIQA NPATAPSEDD SEIKKIKKVQ SFLRGWMCRR KWKTIIQDYI RSPHAESMRK
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLE YAKSKLEELS
RIMHDEVSET ENIRKNLAIE RMIIEGCEVL LDTSQTFVRQ GSLIQVPMTE KGKIPRGRLG
SLSLRKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVVSL IDCTLMEEPE GTDDESKPDK
SGQDMEHLDF KVIVEPKDGQ SFTVILVASS RQEKSAWTSD ISQCIDNIRC NGLMMNAFEE
NSKVTVPQMI KSDASLYCDD VDIRFSKMMN SCKVLQIRYA SVERLLERLT DLRFLSIDFL
NTFLHSYRVF TTADVVLDKL IAIYKKPISA IPARSLELFF ASSQNNKLLY GEPPKSPRAS
RKFSSPPPLS IGKSSSPNRR RKLSLNIPII TGGKALDLAA LSCSPNGYTS MYSSVSPFSK
TTLDISKLYI SSSASSKIPD EGEAKADRTE DSSRCKQGWY NSVREECDID QNQSDDAETD
TSPTKSPTTP KNVKSKSSSG FPTDQRNGDK EFVIRRAATN RVLNVLRHWV SKHSQDFDSN
TELKQKVISF LEEVIHDPEL LTQERKAPWA ARMTTGNHAG KAEPFENHSA LEIAEQLTLL
DHLVFKVIPY EEFFGQGWMK NDKSERTPFI MKTTKHFNDI SNLIATEILR CDEVNTRVAV
MEKWVAVADI CRCLHNYNAV LEITSSLNRS PIFRLKKTWL KVSKQTKTVI DKLQRLVSSE
GRFKNLREAL KNCDPPCVPY LGMYLTDLAF IEEGTPNYIE DNLVNFSKMR MVSQTRAYYQ
HSVLDEESLY EESLRIEPKM PT
//