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Database: UniProt
Entry: A0A3B3SAJ0_9TELE
LinkDB: A0A3B3SAJ0_9TELE
Original site: A0A3B3SAJ0_9TELE 
ID   A0A3B3SAJ0_9TELE        Unreviewed;      1162 AA.
AC   A0A3B3SAJ0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Ras-specific guanine nucleotide-releasing factor 1 {ECO:0000313|Ensembl:ENSPKIP00000027021.1};
GN   Name=RASGRF1 {ECO:0000313|Ensembl:ENSPKIP00000027021.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000027021.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000027021.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3SAJ0; -.
DR   Ensembl; ENSPKIT00000007784.1; ENSPKIP00000027021.1; ENSPKIG00000009181.1.
DR   GeneTree; ENSGT00940000157599; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd13261; PH_RasGRF1_2; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          22..129
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          240..426
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          456..586
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          633..748
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          949..1162
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          710..739
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          796..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          829..872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          157..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        800..814
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        836..865
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1162 AA;  133075 MW;  A38D2FA201A5C46D CRC64;
     MQKGVRLNDG HVTYLGLLAK KDGTRRGCLS KKSSDNTKWH TKWFALLQNM LFYFENESSS
     RPSGLYLLEG CVCDRAPSPK PSLTAKECLE KQYYFTISFN HESQKPLELR TEDAKDCDEW
     VAAITHASYR NLATEHEALM QKYLHLLQIV DTEKTVAKQL RQQIEDGEIE IERLKSEIAG
     LLKDNEKIQA NPATAPSEDD SEIKKIKKVQ SFLRGWMCRR KWKTIIQDYI RSPHAESMRK
     RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
     QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
     KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLE YAKSKLEELS
     RIMHDEVSET ENIRKNLAIE RMIIEGCEVL LDTSQTFVRQ GSLIQVPMTE KGKIPRGRLG
     SLSLRKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVVSL IDCTLMEEPE GTDDESKPDK
     SGQDMEHLDF KVIVEPKDGQ SFTVILVASS RQEKSAWTSD ISQCIDNIRC NGLMMNAFEE
     NSKVTVPQMI KSDASLYCDD VDIRFSKMMN SCKVLQIRYA SVERLLERLT DLRFLSIDFL
     NTFLHSYRVF TTADVVLDKL IAIYKKPISA IPARSLELFF ASSQNNKLLY GEPPKSPRAS
     RKFSSPPPLS IGKSSSPNRR RKLSLNIPII TGGKALDLAA LSCSPNGYTS MYSSVSPFSK
     TTLDISKLYI SSSASSKIPD EGEAKADRTE DSSRCKQGWY NSVREECDID QNQSDDAETD
     TSPTKSPTTP KNVKSKSSSG FPTDQRNGDK EFVIRRAATN RVLNVLRHWV SKHSQDFDSN
     TELKQKVISF LEEVIHDPEL LTQERKAPWA ARMTTGNHAG KAEPFENHSA LEIAEQLTLL
     DHLVFKVIPY EEFFGQGWMK NDKSERTPFI MKTTKHFNDI SNLIATEILR CDEVNTRVAV
     MEKWVAVADI CRCLHNYNAV LEITSSLNRS PIFRLKKTWL KVSKQTKTVI DKLQRLVSSE
     GRFKNLREAL KNCDPPCVPY LGMYLTDLAF IEEGTPNYIE DNLVNFSKMR MVSQTRAYYQ
     HSVLDEESLY EESLRIEPKM PT
//
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