ID A0A3B3SBF5_9TELE Unreviewed; 387 AA.
AC A0A3B3SBF5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Delta like non-canonical Notch ligand 2 {ECO:0000313|Ensembl:ENSPKIP00000027803.1};
GN Name=DLK2 {ECO:0000313|Ensembl:ENSPKIP00000027803.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000027803.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000027803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B3SBF5; -.
DR STRING; 1676925.ENSPKIP00000027803; -.
DR Ensembl; ENSPKIT00000008575.1; ENSPKIP00000027803.1; ENSPKIG00000009706.1.
DR GeneTree; ENSGT00940000160761; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF423; PROTEIN DELTA HOMOLOG 2; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF00008; EGF; 3.
DR Pfam; PF12661; hEGF; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..387
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017292802"
FT TRANSMEM 318..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..126
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 128..169
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 171..207
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 209..245
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 116..125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 159..168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 197..206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 235..244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 387 AA; 41869 MW; 56B916E7563265D4 CRC64;
MDANFSLNLL LCLLCLPIQL CTGQEADCPC NMSHGRCDES GVCRCDPGWE GPQCEDCVRK
PGCVHGSCHQ PWQCTCDSGW AGRFCDKDIY VCTNEKPCQN GGTCFTDDMG EYACSCPEGF
RGRNCELKMG PCEKTRSPCK NGGLCEDDRG YAAQLMCRCL AGFSGPRCEV DVDDCVLQPC
ANGATCLDGV NRFSCLCPPG YTGRFCTVNV DDCASRPCAN GGRCLDRVAT FHCHCPPGFA
GKTCEMLLRN LNAEANTPSW TSHGWAGTEG GVTPPRPHLT AASNASNWAT ADGGQRLLKI
SVKEVVTQRG VALTEVQLIT LLVLGGMTVA VVGMTAVLVL RGHWRDRSTR YSPPPGRLMP
AERECNISFL HSPTLRLEKK QLNTDVI
//
