ID A0A3B3SBP4_9TELE Unreviewed; 1028 AA.
AC A0A3B3SBP4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSPKIP00000027893.1};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSPKIP00000027893.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000027893.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000027893.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3B3SBP4; -.
DR Ensembl; ENSPKIT00000008666.1; ENSPKIP00000027893.1; ENSPKIG00000009615.1.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 71..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..251
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 362..644
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 658..776
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 778..1028
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1028 AA; 114219 MW; E65604DEC2A3CD6F CRC64;
FINNTDNDTG TLYDRKNMAL FEEEMDSNPM VSSLLSNLAN YTNLTQGVIE HEEEDDDEGQ
RKQTVKSPQM GTFMGVYLPC LQNILGVILF LRLTWIVGTA GIMESLAIVS MCCTCISEIT
YTSIMNNGFS AGGSYYMISR SLGPEFGGAV GFCFYLGTTF AGSMYILGTI EILLTYIVPS
AAIFKAEEKE QEAEALLNNM RVYGTCCLAL MALVVFVGVK YVNKLALVFL ACVVLSILAI
YAGVIKTTFD PPNFPVCLLG NRTLKNHNFD KCLKTEEVGN GTVTTKLWQL FCNSSELTAA
CDKYFELNNV TAIQGIPGLM SGVISENMWG SYGPVDTLVE KKHYPSIPAA DSSMDINLPY
VSNDIATFFT LLVGIYFPSV TGIMAGSNRS GDLRDAQRSI PIGTILAIVT TSLIYISCVV
LFGTCIEGVL LRDKYGDSVK GNLVIGTLSW PSPWVIVIGS FFSCCGAGLQ SLTGAPRLLQ
AIARDGIVPF LEVFGHGKAN GEPTWALLLT AAICESGILI ASLDAVAPIL SMFFLMCYLF
VNLACAVQTL LRTPNWRPRF KFYHWALSFL GMSLCLSLMF ISSWFYALVA MVIAGCIYKY
IEYRGAEKEW GDGIRGLSLN AARYALMRLE EAPPHTKNWR PQLLVLLNLD SELAVKHPRL
LSLTTQLKAG KGLTIVGSVL EGTYLTKGLE AKRAEQNIKS TMSTERTKGF CHVVVSSNMR
DGFSHLIQSA GLGGMKHNSV LMSWPGSWKQ GVDHACLTNF VETVRETTAA HQALLVAKNV
DNFPANQDRL NEGTVDVWWI VHDGGMLMLL PFLLRQHKVW RKCKMRIFTV AQMNDNSIQM
KKDLQMFLYH LRLDAEVEVV EMHDSDISAF TYEKTLVMEQ RSQMLKQIHL SRTEQEREAQ
LIHDRNTASH GSSHGSDATP DRVHMTWTKE KMFSERNRNR EVNVGVRDLF NMKPNQSNVR
RMHTAVKLNE VVLNKSQEAH LVLLNMPGPP KHRGGNENYM EFLEVLVEGL NRVLLVRGGG
REVITIYS
//
