ID A0A3B3SDY7_9TELE Unreviewed; 1635 AA.
AC A0A3B3SDY7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Collagen alpha-1(IV) chain-like {ECO:0000313|Ensembl:ENSPKIP00000028186.1};
GN Name=COL4A1 {ECO:0000313|Ensembl:ENSPKIP00000028186.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000028186.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000028186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR STRING; 1676925.ENSPKIP00000028186; -.
DR Ensembl; ENSPKIT00000008962.1; ENSPKIP00000028186.1; ENSPKIG00000009917.1.
DR GeneTree; ENSGT00940000157678; -.
DR OrthoDB; 2882192at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1104; COLLAGEN ALPHA-1(IV) CHAIN; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 15.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1635
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017307099"
FT DOMAIN 1411..1635
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 59..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..785
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1383..1400
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1635 AA; 160464 MW; 858C7A76D5AFDB1D CRC64;
MPSHIVLFFM VFTNLHRATA DGCLESSCGK CDCSGVKGSK GEQGLPGMQG VMGFPGRVGP
EGHPGPMGPK GDGGVPGAPG HEGIRGPPGV AGYPGNPGFP GIPGQDGPPG QRGIPGCNGT
KGERGFDGTP GFPGAQGPPG TPGIPGMKGE PGGLTSTYIP SKGEKGSPGH PGFRGSPGQP
GISGPIGPPG PMGMGGDPGS PGQKGEKGNM VNFVGEKGEK GTQGLRGPPG PPGEFPEREG
PPTTYINGPK GDSGEKGDKG EKGFCVPYLH GLKGEPGPQG PRGKPGKDGE NGINGEAGYP
GDPGRPGLAG QKGEKGLPGN GNAPGPPGQR GPPGMKGERG PPGSHGDIGP PGRYVSGPPG
SPGFPGEMGQ KGDKGADGLP LKGQAGRQGL PGPPGPPGLV GVDCDIKHGP PGPPGPPGLQ
GEIGQKGDQG DVCVNCQAIA FPGPPGPQGP PGHQGFPGPA GPKGEGGEPG PRGPSGNPGL
HGPRGLMGAP GAQGAPGDYL VAPGLKGDKG YPGLKGVRGS PGYNGHPGKD GLPGLPGEKG
EPATMGVKGD RGKDGDVGLI GPRGERGPPG QSAFGYPGKP GEKGSRGEAG RPGAAGREGL
KGEAGIGISL PGPQGAPGSS GPMGRPGIPG SQGEQGTPGF PGVKGLKGDI GLQGIGQPGL
PGPKGYSGVP GAPGLPGEAG QHGKDGNTGY SGVPGQKGEA GRGLPGPKGL MGPQGTIGFP
GDKGRVGPPG IPGKEGVTGP PGLQGITGDV GPPGQPGFEG PTGPPGPGDP GLPGPHGPPG
YPGNTGPPGV KGNKGDPGGP GLDMPGPRGE KGDQGFPGHQ GQKGSLGQLG PPGRDGFPGL
QGIKGDRGGI GLPGTPGYHG PSGNPGAPGQ RGDPGLPGLR GVFGEHGPKG ERGDAGLRGP
PGNMTDIDMN SMKGDKGDAG PQGTPGYAGD KGYLGEPGKP GMPGKEGMPG SPGQPGDKGE
RGEPGEPGRT GHPGQKGHSG DMGLPGSDGP KGDKGLVGSP GHPGFPGTSG HKGQKGDAGL
PGIGMPGPPG EKGEKGFTGS IGFTGEKGQK GRMGEHGMPG HPGTKGDKGY DGPQGTPGQP
GEKGVLGLPG LPGDPGSQGR PGEAGRQGPP GSHGEKGLPG QDGIPGSTGE RGDSGLPGRG
FPGPPGQAGF KGDKGSDGLP GIPGIPGVPG AKGDKGRPGD QGQQGQSGLQ GLPGPSMEGA
KGDRGLPGGL GWPGDIGAPG PIGVPGNIGA RGDKGDEGFQ GNPGSKGFKG DRGSPGYPGG
YGLPGINGQK GEKGLQGSPG FPGLKGDKGF LGTKGVQGDS GYPGVKGNEG PPGPPGPQTF
IKGDVGLPGP PGPQGPQGFL GNPGMKGYQG MTGQMGIKGE EGQPGYDGRS GVKGEPGPIG
PSGPRGFLGP PGPDGVPGPA GLPGPASKEH GFLVTRHSQT VELPLCPHGT TLMYEGYSLL
YVQGNERSHG QDLGTSGSCL RKFSPMPFLF CNINNVCNFA SRNDYSYWLT SPEPMPMSMA
PITGENIKPF ISRCAVCEVP AMVIAVHSQS VRIPSCPAGW DSLWIGYSFV MHTSAGAEGS
GQALASPGSC LEEFRSAPFI ECHGRGTCNY YANSYSFWLA TIEDNEMFRK PEPATLKAGS
LRTHVSRCQV CMKRT
//
