ID A0A3B3SE98_9TELE Unreviewed; 3450 AA.
AC A0A3B3SE98;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Heparan sulfate proteoglycan 2 {ECO:0000313|Ensembl:ENSPKIP00000029082.1};
GN Name=HSPG2 {ECO:0000313|Ensembl:ENSPKIP00000029082.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000029082.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000029082.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPKIT00000009872.1; ENSPKIP00000029082.1; ENSPKIG00000009289.1.
DR GeneTree; ENSGT00940000156670; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0072359; P:circulatory system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00055; EGF_Lam; 6.
DR CDD; cd05743; Ig_Perlecan_like; 1.
DR CDD; cd05754; IgI_Perlecan_like; 1.
DR CDD; cd00110; LamG; 3.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR12231:SF267; BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN; 1.
DR PANTHER; PTHR12231; CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07679; I-set; 5.
DR Pfam; PF13927; Ig_3; 7.
DR Pfam; PF00052; Laminin_B; 3.
DR Pfam; PF00053; Laminin_EGF; 7.
DR Pfam; PF00054; Laminin_G_1; 3.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00409; IG; 12.
DR SMART; SM00408; IGc2; 12.
DR SMART; SM00406; IGv; 5.
DR SMART; SM00281; LamB; 3.
DR SMART; SM00282; LamG; 3.
DR SMART; SM00192; LDLa; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF48726; Immunoglobulin; 13.
DR SUPFAM; SSF57424; LDL receptor-like module; 4.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 4.
DR PROSITE; PS50835; IG_LIKE; 13.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR PROSITE; PS51115; LAMININ_IVA; 3.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 4.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 337..414
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 477..662
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 696..745
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 746..803
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 875..1052
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1086..1135
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1242..1461
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1495..1544
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1587..1695
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1701..1787
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1816..1899
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1910..2021
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2029..2113
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2124..2207
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2215..2303
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2311..2385
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2401..2483
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2487..2525
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2539..2623
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2628..2704
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2716..2899
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2895..2932
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2935..2973
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2979..3159
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3155..3192
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3194..3227
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3252..3448
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1961..1988
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 164..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 171..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 183..198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 216..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 223..241
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 235..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 256..268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 263..281
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 275..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 319..334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 715..724
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 774..783
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1105..1114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1514..1523
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2922..2931
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2944..2961
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2963..2972
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3182..3191
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3217..3226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3450 AA; 377290 MW; CD2D4AAE007FB18A CRC64;
SFLRPSYLFN IKVTVSLTRR AEIHLEGSVA VCLHFVRVTM RCCTCLTTPP PLPPIPVYYR
ALVNFTNSFV YGPELEDINS PLFKEITDAV VDTVPDPHGP LLFRKLGNNV FVELDVGSEV
NMNTEQIRNV LFSVVKEGSI ASYITSVHGF QFRRLGVDDN RQPCTDSEFT CRDGECIPSE
YRCDKRHDCR DMSDESDCVL AGPRPPVLKP PVLRPCRADQ ATCQNGQCIP RDYLCDGERD
CSDGSDELAC GTPSPCEPNE FKCQNGHCAL KLWRCDGDND CGDNSDESYC PVKSPGDTCA
PEQFVCVRDR TCIPASYQCD EEPDCPDRSD EIGCTPPTIT SPPEESVMAM RGETVTFTCK
AVGVPTPIIT WRLNWGHIPN SSRISMASVN GHGTLTIQDV KDGDQGAYTC EAINAKGMVF
GIPDGVLTVK PNTAGHCTGG HFGAGDGSAC IPCFCFGITK NCQNTGRHRN QIRLRFTEED
NFKGVNVSFP SRPASPPLSS TQLLINTEVE EFQLVDLSRR FLSLESFWTL PSQFLGNKVD
SYGGSLNYKV RFTLARGETE PVQKPDVVLV GNGQKLIYRR TSPTSPRITN EREIKFTEEN
WQHASGRLVT REDLMMTLVN LESINIRTTY DNRMVSVALR DIVMDTTTVE FSGQGPANDV
EQCRCPPGYS GLSCESCASG FERVSGGSYL GSCAGCNCNG HASACDPISG HCLSCQHNTE
GPQCNKCRPG YFGDPTRGRS DDCKPCPCPY IETSRRFSDT CFLDSDSQAT CDACRPGYTG
RRCEKCAPGY HGNPLQPNGK CVPQSECISC FTGLTFNRDS ALQSNVVGAL CDECRSSSFH
LTEDNPDGCL QCFCMGVTKQ CTSSTWSRDQ VRGGVNGQLF SLANAAHTRT ISDGIGQRGG
SEVIFRFSTH VPHDVLFWVL PESFRGDKVT AYGGELRYTV SYVPRQHSAP IEGQPDVVLQ
GNGIMLEHYS STKPTPHVAT VITVPFRESE WKRSDRQPCT REHLLMALAD ITVFMIRATY
ANSMTETGIA DIWMDIAVPH STGNERALEV EECACPQGYR GPSCQECDVG YIRTGSGLYL
GTCERCNCHG YATTCDPDTG NCLQCQHNTA GPHCDRCRPG YYGNPRSGSP AACQPCPCPG
TSPDIQFSRT CFLDSDGQPT CDGCPPGFTG RRCERHVLIT LYLPLLQAYV EGPLCAQCKP
GHFHLSPAHK DGCLSCFCMG ITQQCSSSSY YRDLVSSSFA PGHFQGFALV NRQRTNRIAT
GFTVEVSTQG TQLSFSRFGN LAQEAHYWQL PEAYRGDKVV CTGHVTRHYA LVYKGFSLYP
EEVLFWQLPP QYKGVKVGSY GGRLKYTLSY VSDPRGSSIE DVDVQIIGND ITLVTRQPWP
RGQGTRESRQ FEVVFKEENW QRPDGMPATR EHLMMVLADL DDILIRASYY TDMRSTSISD
VSMEVAVPNY TGLTQALEVE ECRCPPGYRG LSCQDCAAGY TRTGGGLYLG HCELCDCNGH
SDSCHPETGV CTSCLHNTMG QMCEQCAAGF FGDPTAGTPE DCQPCACPHT DPENQFSHTC
ESTGNGGYQC TACQRGYTGQ YCERCSPGYV GNPQERIKCH IHSDAVSLVV RIQPERVQVS
QGGSVTLRCQ VTSLPPHKFQ WSREDGRSLS SNAEIHRHGE ELHFSSVQPH DAGVYICTCQ
DQHNTNRSRA EIVVTAVSTK PIEVTVEEPK TQSVRVGSTI HFICTAKSKS PAYTLVWTRQ
GRGNLPDRAV DFNGILTIHN VQPEDAGIYV CTGSNMLAMD EGTAILHVPE PSQTQMFYTA
YEMFEGHRLP ADGSQPVATV HPPVLSVQQG QRAEFRCTVT GNPPPVIEWI GGPGGRINRN
AVIRGEVLSI PAVERADEAE YICKALNVHG EHAARAMLYV HSASPKSLLP QVQVSPQTVD
IHEGETLRLY CRAGGTPTPG LDWKRREGPL PQQAIPSHGF HQFKSNSLDV LQKRIEELQA
RMERTDIGTL LIPNIKASDA GTYLCVGTNS IGSSEASIKV KVIKADPIPT WITILPQVAT
VQEGQWLDLS CVVPGNFPAS VTWRRTDRPL SSNHQVLLYI VLRILQASAD DAGEYTCRVQ
GGPAHQQASV TVSVTSSTSR LQTPIISIEP HSTAVRLGEA ASFRCYIYSG AQPVHLEWKL
AGNQPLPDNV KVGPDNSVIT ITNAQPRNQG PYHCVASNRF GITRSIASLI VKDSPKVTVT
PKSPVRVWVG EPINLECQAR GDPRPSVSWH RMDNSHRIVL NSPVPMESNA VMQVLVARPE
DSGTYICTAQ SSEGTSEARV EVIIEGGAQV PSFPIASVPE TFMVVKEGQT VTLHCNAQGY
PTPTITWSKL RAPLPWRHSV VNNTLVLTSV GRQDSGQYIC NATNNLGVSE VLIMLDVETP
PYATTLPDDL SVRVGEVIRL QCLSHGTPPL TFRWTKVNGS MSARAEVRGG NLQINLATAN
DVGTYKCAVS NKVGSSEALA RVIVRSPLEV RVYPQVEVKA PGSAVEFTCS ANGGIQTTVE
WLKEGGSLPA NHHIKDALPK VMINIRTSVQ TVMLGSSVEF ECHATGDPEP TVQWSKVDGT
LFSHVVVKGG MLTINRVTEV DAGKYRCTAT NNVGSVQSEV ILNVQTLPQI TAQPEVREVT
VGSTAVFPCM ASGYPLPQIT WTKLEGPLAP KASQEGHVLT IPNVTFEDSG TYVCTASNKQ
GKVQAFSMLK VHERIMPYFT QTPLSYLTLP TIKNSYKAFN IKITFRPDNV DGVILYAGMI
LYNGQKRTTG ADFISLGLVG GRPEFRFDVG SGMATIRFPT PIKLGEFHTV ELYRNTTQGA
IIVDGQAPIN GSSQGKFQGL DLNEELHVGG YPNYSIVSKT TGLKNGFVGC IRQLIIQGDE
VIFKDLDRSS TGVSNCPTCK DRPCQNGGVC QDSETSNYKC ECVRGFTGSN CEHHSSMHCH
PEACGSDATC INNPSGRGYD CRCHLGKFGE KCMHGTLVTT PLFNGEDSFI TYPPLTNIHN
DLRVDLEFKP MEANGLMFFS GGKKMKVEDF VSLAMVDNHI EFRYELGTGM AVLRSRDPVK
LGQWHQIEAE RIDRDGSLKV DQAREVRRSS PGKAQGLNIY TPMYLGGVPS MDILPKPANI
SMLFKGCIGE VSINGKKVDL SYSFTESQSI SQCVDANPCE RRPCRNGGTC LYSAEYEFQC
LCQDGFEGEL CEVVKDTCQH NSECQNGGRC LANRCVCSSG FTGLFCETRH SLSFPDAMWD
LEGSGGNDSP AEYAAYFHDN GYLALPKSVF PRSSLDAPEV IELEIRTASS EGLILWQGVV
GLWAQENELG DQGKGKDFIS LGLQNGHLVF SYQLGSGEAK ITSKEPINNA DWHMVRAVRT
GKQGYIQVDG GPISRGLSRG ESVMVNTKGD IYLGGAPNMV ALTGGKFSTG ITGCIRNLVL
ANTLPWDRQL QPIDILAHSG EGINVERCSS
//
