ID   A0A3B3SG91_9TELE        Unreviewed;      1655 AA.
AC   A0A3B3SG91;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Golgi brefeldin A resistant guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSPKIP00000029280.1};
GN   Name=GBF1 {ECO:0000313|Ensembl:ENSPKIP00000029280.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000029280.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000029280.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
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DR   Ensembl; ENSPKIT00000010073.1; ENSPKIP00000029280.1; ENSPKIG00000010267.1.
DR   GeneTree; ENSGT00940000156925; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0051641; P:cellular localization; IEA:UniProt.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.220.20; -; 1.
DR   Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   PANTHER; PTHR10663:SF388; GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   Pfam; PF12783; Sec7-like_HUS; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF48425; Sec7 domain; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT   DOMAIN          499..689
FT                   /note="SEC7"
FT                   /evidence="ECO:0000259|PROSITE:PS50190"
FT   REGION          20..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1090..1135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1239..1290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1528..1600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1091..1124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1529..1572
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1655 AA;  184863 MW;  3E0D6283C1B3FDB0 CRC64;
     MVQQLFSRLP QFKEEAKGFV GTNMKKLKMR AGGMSESTKW KKQKRSPRPP RHTARSSSGQ
     SEPPQHTTLS NNLSGGMLFV EEQQSALPAS DSAASSISSP VPDSGLDTSS KATSHEDLTD
     LEQSSSTATT PGTMAPPELP QPDPQCEGQQ VERAQSASVE SIPEVLEDRD SVAEQSDSAS
     VHDMDYVNPR GVRFTQPSQK DGVAPMPYGL PCLRELFRFL ISLTNPHDRH NSDVMLHMGL
     QLLTVALEAA YIAPYQSLLG LVKDELCRHL FQLLSMDRMN LYASSIRVCF LLFESMREHL
     KFQLEMYLKK LMDIITSENA KMPYEMKEMA LEAIVQLWRI PSFVTELYIN YDCDYYCSNL
     FEDLTKLLSK NAFPVSGQLY TTHLLSLEAL LTVIDSIEAH CQAKVLNNTV QQDQSETLTA
     DGESTVCDGT RTVTEAERLP TVRNGPEADV SPLCHTSAGH LIGDRLRQGR QDQEEPDLAE
     KKLPKKPLRF SSCFPDSQEL LDIKNKKKLL ITGTEQFNQK PKKGIQFLQE MGLLSSPMDN
     GEVAQWLREN PWLDKKMIGE FVSDRKNMEL LDSFVNTFAF QGLRIDEALR LYLEAFRLPG
     EAPVIQRLLE TFTDNWHKVN GSPFMTNDAG FALAYAIIML NTDQHNHNVR KQNIPMTVEQ
     FKKNLKGVNG SKDFDQDMLE DIYNAIKNEE IVMPDEQTGL VKENYVWSVL LHRGATSEGI
     FLHVPPGSYD HDLFTMTWGP TIAALSYVFD KSLDDAIIQK AIAGFRKCAM ISAHYGFSDV
     FDNLIISLCK FTTLSSESID NLPSVFGSNP KAQVAARTVF SLAHRHGDIL REGWKNIMDS
     MLQLFRAELL PKALVEVEDF VEPSGKISLQ REETPSNRGE SAVLSFVNWL TLSGAEPSGL
     RGPSTENQEA KQAAMQCIKQ CDPEKLITES KFLQLESLQE LMKALISVTP DEETYDEEDA
     TFCLEMLLRI VLENRDRVSC VWQAVRDHLC HLCVHAMESC FLVERAVVGL LRLAIRLLRR
     EDISSQVLLS LRLLLMMKPH VLSRVSREVA YGLHELLKTN AANIHCSDDW FTLFSLLECI
     GAGVKPPASL QLTSGPDSDT GAQSDSELSS YHPSEVSLDR GYTSDSEVYT EHGKSRMPRS
     ITDVDVANSG WLVVGKDDLD AAKSVAPSTK PPTPPLVNQY SLTLGQDMGL HDTKSLIKCV
     ESLSFIVRDA AHVTPENFEL CVRTIRVFVE ASLNGGYRTH EKKRSHKYDT KSSRMRRRPR
     EKEAAARRVK ASSQRPSRPH SDEEEDEGVP ASYHTVSLQL LDLMHTLHTR AASIYSSWAE
     ELHHQETSGK KVEADSQTLW SSCWCPLLQG IAWLCCDARR QVRMQALTYL QRALLVHDLQ
     TLDAVEWESC FNKVLFPLLT KLLDNISPAD VGGMEETRMR ACTLLSKVFL QHLSPLLSLP
     TFAALWLTIL DFMDKYMHAG SSDLLLEAIP ESLKNMLLVM DTAGIFHCAD SRTGYSDLWE
     ITWERIDCFL PRLRQELFKQ AVMPEPVSSV PVEPSPAPAP RTASPVPATP PEPKIPSRPE
     SPQEPPPLSA NERSSPVPST MPVPIPVKMS PSEAPPTINQ SSPLILQPLA SPLQVGVPPM
     SLPIILNPAL IEATCPVPLL PASRPTEPSD VSEVK
//