ID   A0A3B3SHP3_9TELE        Unreviewed;       748 AA.
AC   A0A3B3SHP3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Signal-induced proliferation-associated 1 like 3 {ECO:0000313|Ensembl:ENSPKIP00000029893.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000029893.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000029893.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3SHP3; -.
DR   STRING; 1676925.ENSPKIP00000029893; -.
DR   Ensembl; ENSPKIT00000010694.1; ENSPKIP00000029893.1; ENSPKIG00000010957.1.
DR   GeneTree; ENSGT00940000159183; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.30.1120.160; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF15; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 3; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 2.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          187..453
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          593..657
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          684..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   748 AA;  82929 MW;  4F072173EBE8B816 CRC64;
     RRSPPPLPPH RAPTLRQDAC PFPSCSPPGP ELRPRTMSSY RDRTHCAPEL SSRSEVETVR
     GELDEGRPPE ARRTWQCPKS FAHYDVQTAS TVSPPRNVSF LSSWAGVGPA GAGPAVSTRC
     ANASVSVLEV APDQQLATRL ERFKHYSIEH VDLGARYYRD YFHGREHSTY FGTDDKLGAV
     AVSIRREKLE DTKDLKDQYQ YRLILRTNEM VTLRGSILED SVASTARHGT ARGLPLKEVL
     ECATPELSVS CLRLALNTPK VSEQLLKLDE QGVSVKEDDK WPQWGKRAER GSGGGSAGRS
     TADSTGTHSL YTTYLDYEVM FHVSTMLPYM PNNPQQLLRK RHIGNDIVTI IFQEPGALPF
     TPQNIRSQFQ HVFVIVRVHN PCTDDVSYSV AVTRMKDVPM FGPPIPNGVT FRNPEVFRDF
     LLAKVINAET AAHKSEKFHT MARRTRQEYL RDLVENCASG TFLDSAGKLN NLISLASKKR
     ERARAREGAE LGALGAVTWR VTAQDFSGGG AELACVLGVS GEYVVLVDCG TKGVVFNCYC
     ADVIGWTPER LALKIYYGRG DHIAVRVPEG WAQDIREIVQ RLKALTVGCE TVDMTLRRNG
     LGQLGFHVRL DGTVAEVEEY GFAWQAGLRQ GSRLVEICKV AAVTLSHEQM IDLLRTSVTV
     KVVIIPPYDE GGPRRHGRCS QIRRGGHPVS KGQDHPSIHP CPPPSPGRLS VFQRNRLLEI
     KTRNMREKEE CLGKGAKSAD GETCLNTA
//