ID A0A3B3SIG4_9TELE Unreviewed; 776 AA.
AC A0A3B3SIG4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Rho guanine nucleotide exchange factor 7-like {ECO:0000313|Ensembl:ENSPKIP00000030522.1};
GN Name=ARHGEF7 {ECO:0000313|Ensembl:ENSPKIP00000030522.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000030522.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000030522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR AlphaFoldDB; A0A3B3SIG4; -.
DR Ensembl; ENSPKIT00000011343.1; ENSPKIP00000030522.1; ENSPKIG00000011301.1.
DR GeneTree; ENSGT00940000155360; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12061; SH3_betaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035789; BetaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..114
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 135..194
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 226..406
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 428..533
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 194..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 725..766
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 556..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 87602 MW; 85AA07E0444968F0 CRC64;
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQSSLKDGVV LCKLLERLRP GSVDKAFDAS
DLLQGEDFSK VLSSLVALNK ATADFGVGSE STCARRSSSH RIKSFDVLAS QPSAGRSSKI
FPNQYRSLDM TENSTCQVAV KARFNFQQTN EDELSFSKAD IIHVTRMEDG GWWEGTLNGR
TGWFPSNYVR EIKGSGGSKD KPVSPKSGTF KSPPKGPDTS GISKTYYNLV VQNILETETE
YSKELQNLLS NYLRPLQSTE KLSSSDIVHI MGNLEEISTF QQMLFQSLEE RTRLPESQQR
LGGFFLNLIS QMRKLYVTYC ANHPSAVSVL TQHSEELGDF MESRGASRPG ILTLTTGLSK
PFMRLDKYPT LLKELERHME EYHLDRPDIQ KCMNSFKNLS AHCQEMRKRK ELELQILNET
IRCWEGEDIR TLGGVIYMSQ VVVNNYGSEE QSERYLLLFP HVLLLLSASP RMSGFIYQGK
LPLTGMTVSK LDDSETHKNA FEISGGMIDR IQVTCSSLQD RQEWLDHLQR QTKLISMATP
NARPSPVPCH TLPSHPGTPS RLSDSRSATL APAYHTLPHS SHGPPHSNPM WGPLEPPKTP
KPWSLSCLRP APPLRPSAAL SYKEDLSKSP KSMKKLLPKR KPERKPSDEE FAQRKSTAAL
EEDAQILKVI EAYCTSAKTR QTLNSRNRKE SGLHMLFPEE EKVIVEEIKS NGQAVMEEKS
LVDTVYALKD EVQELKQDNK KMRRTLDEEQ RARKELEKIV RKVLKNMNDP WDETNL
//