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Database: UniProt
Entry: A0A3B3SIG4_9TELE
LinkDB: A0A3B3SIG4_9TELE
Original site: A0A3B3SIG4_9TELE 
ID   A0A3B3SIG4_9TELE        Unreviewed;       776 AA.
AC   A0A3B3SIG4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Rho guanine nucleotide exchange factor 7-like {ECO:0000313|Ensembl:ENSPKIP00000030522.1};
GN   Name=ARHGEF7 {ECO:0000313|Ensembl:ENSPKIP00000030522.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000030522.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000030522.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC       {ECO:0000256|ARBA:ARBA00004510}.
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DR   AlphaFoldDB; A0A3B3SIG4; -.
DR   Ensembl; ENSPKIT00000011343.1; ENSPKIP00000030522.1; ENSPKIG00000011301.1.
DR   GeneTree; ENSGT00940000155360; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd01225; PH_Cool_Pix; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd12061; SH3_betaPIX; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035789; BetaPIX_SH3.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR032409; GEF6/7_CC.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR046376; PH_Cool_Pix.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR   PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR   Pfam; PF16523; betaPIX_CC; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF16615; RhoGEF67_u1; 1.
DR   Pfam; PF16614; RhoGEF67_u2; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          1..114
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          135..194
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          226..406
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          428..533
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          194..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          539..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          621..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          725..766
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        556..570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        641..657
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   776 AA;  87602 MW;  85AA07E0444968F0 CRC64;
     MNSAEQTVTW LITLGVLESP KKTISDPEGF LQSSLKDGVV LCKLLERLRP GSVDKAFDAS
     DLLQGEDFSK VLSSLVALNK ATADFGVGSE STCARRSSSH RIKSFDVLAS QPSAGRSSKI
     FPNQYRSLDM TENSTCQVAV KARFNFQQTN EDELSFSKAD IIHVTRMEDG GWWEGTLNGR
     TGWFPSNYVR EIKGSGGSKD KPVSPKSGTF KSPPKGPDTS GISKTYYNLV VQNILETETE
     YSKELQNLLS NYLRPLQSTE KLSSSDIVHI MGNLEEISTF QQMLFQSLEE RTRLPESQQR
     LGGFFLNLIS QMRKLYVTYC ANHPSAVSVL TQHSEELGDF MESRGASRPG ILTLTTGLSK
     PFMRLDKYPT LLKELERHME EYHLDRPDIQ KCMNSFKNLS AHCQEMRKRK ELELQILNET
     IRCWEGEDIR TLGGVIYMSQ VVVNNYGSEE QSERYLLLFP HVLLLLSASP RMSGFIYQGK
     LPLTGMTVSK LDDSETHKNA FEISGGMIDR IQVTCSSLQD RQEWLDHLQR QTKLISMATP
     NARPSPVPCH TLPSHPGTPS RLSDSRSATL APAYHTLPHS SHGPPHSNPM WGPLEPPKTP
     KPWSLSCLRP APPLRPSAAL SYKEDLSKSP KSMKKLLPKR KPERKPSDEE FAQRKSTAAL
     EEDAQILKVI EAYCTSAKTR QTLNSRNRKE SGLHMLFPEE EKVIVEEIKS NGQAVMEEKS
     LVDTVYALKD EVQELKQDNK KMRRTLDEEQ RARKELEKIV RKVLKNMNDP WDETNL
//
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