ID A0A3B3SMK6_9TELE Unreviewed; 1313 AA.
AC A0A3B3SMK6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRK {ECO:0000313|Ensembl:ENSPKIP00000031535.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000031535.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000031535.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR Ensembl; ENSPKIT00000012382.1; ENSPKIP00000031535.1; ENSPKIG00000011558.1.
DR GeneTree; ENSGT00940000156249; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14636; R-PTPc-K-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF11; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..175
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 177..262
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 275..368
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 369..475
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 767..1010
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 930..1001
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1042..1304
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1218..1295
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1313 AA; 147789 MW; D30ADB5982CD7778 CRC64;
RSSGCGRCVL PLCLSGGCTF DNGPAQCDYQ QDPYNDFDWT HVSAQEVPFL SSELPQGSYM
MVDSSQHDPG EKARIQLPIM KENDTHCIDF NYLLYSHDGS SPGTLNVLVR VNKGPLANPI
WNVTSYTGKE WLRAELAVST FWPNEYQVIF EAVSDEKSGY IAIDDIQVLS YPCDKSPHFL
RLGDVEVNAG QNATFQCIAT GRDAVNNKLW LQRRNGEDIP VAQTKNINHR RFAASFKLKE
VTSLDQDLYR CVTQSERGSG VSNFAGLIVR EPPRPIAPPQ LLAVGPTYLL IQLNANSIFG
DGPIILKEVE YRMTSGSWTE THAVNSPNYK LWHLDPDTEY EIRVLLTRPG EGGTGQPGPP
LITRTKCAVP GPVPSKSMRA KPFEDRILLY WKEPLEPNGI ITQYEISYSS VRSFDPSVPL
LRPPLIVSLP WNSSHHVFSQ LHPGTTYQFV IRASTVKGFG PPTTLNVTTN ISAPTLEEYD
GSEACLNETA TTITVLLKPA QAKGAPISAY QIVVEELNPH RSRREASSVD CYQVPVSFHS
ASSGGSPYYF AAELPPSNLL EPSPFTVGDN KTYHGFWNPP LAPRKNYNIY FQAVSSVEKE
TKTQCLRLAT KGATEEPEVI PDPAKQTDRV VKIAGISAGV LVFILLVLVA ILLVKKRKLA
KKRKDAIGNT RQEMTHMVNA MDRSYADQST LHSEDPMSVT FMDSHTFNNR YENHSAAAES
SRLLDVPRYH CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA
SWDVAKKEQN RTKNRYGNII ACKYPVWSVI SSNKVANSCT SMGTRNGVSP VHETVYDFWR
MIWQEQSACI VMVTNLVEVG RVKCYKYWPD DAEVYGDFKV TFVEVEPLAE YVVRTFTLER
RGFNELREVK QFHFTGWPDH GVPYHATGLL SFIRRVKMSN PPSAGPIVVH CSAGAGRTGC
YIVIDIMLDM AEREGVVDIY NCVKALRSRR INMVQTEEQY IFIHDAILEA CLCGETAIPA
CEFKAAYYEM IRIDSQSNSS HLKDEFQTLN SVTPQPQPED CSIALLPRNH EKNRFMDTLP
PDRCLPFLIT IDGESSNYIN AALMDSYRQP AAFIVTQHPL PNTVKDFWRL VYDYGCTSLV
MLNEIDLAQG CPQYWPEEGM LRYGPVQVEC MSCSMDCDII SRLFRICNLT RPQEGYLMVR
QFQYLGWAAH REVPASKRSF LKLILQVDKW QEECEEGEGR TIIHCLNGGG RSGMFCAVSI
VCEMIKRQNV VDVFHAVKSL RNSKPNMVES PEQYRFCYDL ALEYIETNQE GAF
//