ID A0A3B3SQ68_9TELE Unreviewed; 797 AA.
AC A0A3B3SQ68;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Volume-regulated anion channel subunit LRRC8C-like {ECO:0000313|Ensembl:ENSPKIP00000032894.1};
GN Name=LRRC8C {ECO:0000313|Ensembl:ENSPKIP00000032894.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000032894.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000032894.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR Ensembl; ENSPKIT00000013773.1; ENSPKIP00000032894.1; ENSPKIG00000012817.1.
DR Ensembl; ENSPKIT00000013794.1; ENSPKIP00000032913.1; ENSPKIG00000012817.1.
DR GeneTree; ENSGT00940000159250; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF22; VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C-LIKE; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..331
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 797 AA; 92639 MW; 581B907150786FE4 CRC64;
MIPVTEFRQF SEQQPAFRVL KPWWDVFTDY LSVAMLMIGV FGCTLQVMQD KVICLPKRMS
LPNETVPSQN TSEIMLDPTL APHANFSPEP VVHEMKGLKT NLDLQQYNYI NQMCYDRALH
WYAKYFPYLV LIHTIIFMVC SNFWFKFPGS SSKIEHFISI LGKCFDSPWT TRALSEVSGD
NPEKKESKKP NLNISTLESN LEESHSLRSI AEKFVVDKPA ARALDKKEGE QAKALFERVK
KFRLHVEEGE LLYIMYVRQT VLKVLKFILI IIYNSNLVPH VRMNVMCNVD IQDMTGYKHF
FCNHTMADLF SKLSYCYLCF VSVYGLTCLY TSIWLFYRSL KEYSFEYVRQ ETGIDDIPDV
KNDFAFMLHM IDQYDPLYSK RFAVFLSEVS ENKLKQLNLN HELTAEKLRQ RLQINSSNRL
ELKFFMLSGL PDTIFEVTEL QSLKLEIMNN VTIPAAIAQL EDLQELSLYQ CSVKTHTAAT
SFLRENLKIL RVKFDDSREL PHWIYSLRNL EELYLIGSLS PDISKNIALE TLRELKSLKI
LSLKSNLTKI PQSIVDVSSH LQQFCVHNDG TKLVMLNNLK KMVNLTILEL VHSDLERIPS
GIFTLTCLQD LDLKDNNLKS IEEIVHFQQL RKLTSLKLWY NAITYIPENI KKLGSLEHLH
FNHNKIEILP SHLFLCNKLR YLDLSFNDIR FIPPEIGVLQ SLQYFSVTCN KIENLPDELF
FCKKLKTLKL GKNTLSLLSP KISYLVLLTH LELKGNHLEV LPAELRSCRN LTRSGFVVED
NLFETLPSDV REQMKLE
//
