ID   A0A3B3SQI7_9TELE        Unreviewed;       319 AA.
AC   A0A3B3SQI7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Transcription factor HES-4-B-like {ECO:0000313|Ensembl:ENSPKIP00000033004.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000033004.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000033004.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B3SQI7; -.
DR   STRING; 1676925.ENSPKIP00000033004; -.
DR   Ensembl; ENSPKIT00000013888.1; ENSPKIP00000033004.1; ENSPKIG00000012881.1.
DR   GeneTree; ENSGT00940000163056; -.
DR   OrthoDB; 2907677at2759; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd11459; bHLH-O_HES1_4; 1.
DR   Gene3D; 6.10.250.980; -; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR   PANTHER; PTHR10985:SF136; TRANSCRIPTION FACTOR HES-4; 1.
DR   Pfam; PF07527; Hairy_orange; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00511; ORANGE; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF158457; Orange domain-like; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        54..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          69..126
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          144..177
FT                   /note="Orange"
FT                   /evidence="ECO:0000259|PROSITE:PS51054"
SQ   SEQUENCE   319 AA;  34704 MW;  3D7AC6E98B1E5F2C CRC64;
     MPADLLEKVT TSPVACASAN GTYTPDKLKN ASEHRKVKLL TSTYAHGVYR LELLAFRCVF
     ILIVYSLLIF QTSKPIMEKR RRARINESLG QLKTLILDAL KKDSSRHSKL EKADILEMTV
     KHLRNLHRVQ MTALTGDITI LSKYRAGFNE CMNEVSRFLS TCDGVNTEVK SRLLNHLSSC
     LGQMIAMGYP QPAPAQQTRH VQPLNVQLPS TLPVSGVSVS CKLSPAEGIS PKIYGGFQLV
     PATDGQFAFL IHNPSFASAA TSVIPVYTKT SMPVTVNCSS ASVVPSPVQG VTLFAGVSRA
     SSVSPGADLE SDGSVWRPW
//