ID A0A3B3SUV1_9TELE Unreviewed; 833 AA.
AC A0A3B3SUV1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000034130.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000034130.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR AlphaFoldDB; A0A3B3SUV1; -.
DR Ensembl; ENSPKIT00000015031.1; ENSPKIP00000034130.1; ENSPKIG00000013523.1.
DR GeneTree; ENSGT00940000157996; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF176; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753}.
FT DOMAIN 642..833
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..103
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 94773 MW; 68E8951F9AF3B953 CRC64;
MDPLTPALQK GPLPPVPLRT ASKLPSAEAP LTKTVDGLHV AQDNNRAGIK FSSDGPGLTL
AVLGFEDHFN DAVKVEETRN QQNRSAAPRE PPPLPPLPPG KGSCNPPSTG AGGLLKDRLP
ATQGRNGTPA TKDQRPPNWN YSPTSNTVRQ VMFSNQAVQR EGLIKHLLTK KENDYVDIQN
FRFFVGTWNV NGQSPDSGLE PWLGCDTEPP DVYAVGFQEL DLSTEAFFYL DSAREQQWME
AVERSLHPKA KYKQIRLVRL VGMMLLVYVK KEHRNYIRDV AAETVGTGIM SKMGNKGGVA
VRFVFHNTSF CFVNSHLAAH VEDFERRNQD YKDICARMSF HLPDCPPLSI VKHDVVIWLG
DLNYRLCIYD ASEVKNHISQ KELKKLQEFD QLNIQRQTRR AFTDFIEGEI GFKPTYKYDP
KTDRWDSSGK CRVPAWCDRI LWRGSSVKQL HYRSHMELQT SDHKPVSSLF SVGVKVVNEQ
RYKKVFEEIV RTMDKMENDF LPSLSLSRRE FAFESVKFRQ LQRQRFVVTN DGQVPCHFAF
IPKLNDSQYC KAWLRAEPCD GFLEPYEKLE INLEVYVSKD SVTLLNSGED TIEDILVLHL
DRGKDYFITI SGNYLPSCFG TSLEALCRMK KPIREIPVSK LIDLERIRMN SLLVDPGGTE
DRPLKIPKEV WLLVDHLFTK SCNQEDLFQT PGMQGELQNI IDCLDTSIPE TIPGSNHSVA
EALLIFLEAL PEPVVCYELY QRCLECSLDI RLCKQLVSQL PRAHRNMFRY LMAFLRELLR
CSHSNNLTAS LVATLFASLL IRPPPNFVGR QTSPDRQKAI NFILTFLMGG DEE
//