ID   A0A3B3SX64_9TELE        Unreviewed;      1002 AA.
AC   A0A3B3SX64;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Probable E3 ubiquitin-protein ligase HERC6 {ECO:0000313|Ensembl:ENSPKIP00000035264.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000035264.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000035264.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3SX64; -.
DR   STRING; 1676925.ENSPKIP00000035264; -.
DR   Ensembl; ENSPKIT00000016192.1; ENSPKIP00000035264.1; ENSPKIG00000014283.1.
DR   GeneTree; ENSGT00940000163989; -.
DR   OrthoDB; 5475808at2759; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   PANTHER; PTHR45622:SF60; UBIQUITIN-PROTEIN LIGASE E3A; 1.
DR   PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00415; RCC1; 5.
DR   Pfam; PF13540; RCC1_2; 1.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS00626; RCC1_2; 3.
DR   PROSITE; PS50012; RCC1_3; 7.
PE   4: Predicted;
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   REPEAT          1..52
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          53..101
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          102..157
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          158..210
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          211..264
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          265..315
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          316..373
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          672..995
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        963
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1002 AA;  112743 MW;  DAE6826C39394DD2 CRC64;
     MYSWGDGSRG HLGLRLQGAG TAVAVPRELA DFPEQVTQVA AGESHTLILS NSGKIWTCGR
     NSSGQLGRRK GTNNVPVALD RPESAVGVAS GQEHCLALCK SGEVLAWGRG SEGQLGTGRF
     DKQLKPRIIR LTMSSSMPTP VIQVACGKYH SLALTKEGEM FSWGRNSYGQ LGLGKAISTQ
     DVPSRVLSLI GVPVIQVCAG GEHSFAISLS GEIYCCGANN VGQLGLNRVD ENGRFTVCAV
     PALRALSVCN ISCGEAHSVV LSKDGDVFTF GEGKHGQLGH NSRNNELRPK KVEGLEGRAK
     QIACGSHHTL VLMASGHLLA FGNGSVGQLG TGRTENQLQP TPVQETWRST GASANTDMKI
     AAGWNVSFIY SAPPQEPVEH IFEKLQRWFP LTPDNTHPGN VERDPALIFS SSSALVASFL
     REREPPLGDP SSVDLHAARR VFGQLQGRSW MDAAAKLVSD LFLHSKHMRS VEIFLILPEC
     QLFQNDQNII DFIQPMARSI INLPESSIKR LRTLWSSLEL ESFKKHLGMW KHALSILLKA
     NLLPVYNTFV KDLLQILKEM HKANKSRKAS QTVPASEFHL LDLNLFPVLF EDLGLWYLWK
     NQEETPETPA IFCRFPFVLD LQRKTFVFQS AATMIKQILM FQMWPIVTPP LCLPLRRFAL
     IEDTFQKLST IDHENFKKDL AVRFVERENS ELTLLDRKDF FLQIFKELFL PESGMFWTND
     SGTLVWFPVK PTQPMKRYFL FGVLCGLAVH NNNTVHLPFP QVLFKKLLNA KPTLEDLREL
     SPELGNTLKN ILEDRDDVAA MDLTYSVSWD GVTVELDPTE KDKPVTNANK YDFVRAYVDH
     ILNKSVETIF GEVKRGFFTV CDVDLVELFQ PHELMELMVG NEEYDWEKFR QNSIYEGAYQ
     SNHPYIKMFW EVFEELSEDE KRTFFLFLTG SKRVPILGMD QVIMRVQCRP EWTEDHSAEA
     LTCHNLLYLP IYPTKEMLKT KLIHAITHNK DFWMDEFKAA QP
//