ID   A0A3B3T2Q9_9TELE        Unreviewed;      1137 AA.
AC   A0A3B3T2Q9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Insulin receptor substrate 2-B-like {ECO:0000313|Ensembl:ENSPKIP00000036950.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000036950.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000036950.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3T2Q9; -.
DR   STRING; 1676925.ENSPKIP00000036950; -.
DR   Ensembl; ENSPKIT00000017904.1; ENSPKIP00000036950.1; ENSPKIG00000015336.1.
DR   GeneTree; ENSGT00940000160883; -.
DR   OrthoDB; 4212441at2759; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR   CDD; cd01257; PH_IRS; 1.
DR   CDD; cd01204; PTB_IRS; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR039011; IRS.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR   PANTHER; PTHR10614:SF2; INSULIN RECEPTOR SUBSTRATE 4; 1.
DR   Pfam; PF02174; IRS; 1.
DR   Pfam; PF15413; PH_11; 1.
DR   PRINTS; PR00628; INSULINRSI.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS51064; IRS_PTB; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
FT   DOMAIN          123..234
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          259..363
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000259|PROSITE:PS51064"
FT   REGION          65..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          576..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          717..761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          844..896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          975..1007
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..625
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        876..892
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        985..999
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1137 AA;  122977 MW;  8B67F71D183CEE18 CRC64;
     MADLLDLQGS GGAMLMLEMP RREIGTKTAA AAAGSADGES GTGAPPSSLL IVGGARLYQH
     VLEERDQQAD CPARRPGPAE DALEASLSKS HSSLNPVPCD ASVNNTQNDP GVSAARSEGV
     DGDVWKCGYL RKQKHGHKRF FVLRGASHTG PSRLEYYDSE KKFRNSLRSA STSSTACPPK
     RVIYLYQCFT VNKRADAKNK YLIALYTKDE CFAMVAENEQ EQEDWYLALS DLMSEGKKGH
     LEADELDDSY GADGPGAVFK EVWQVNVKPK GLGQTKNLTG VYRLCLSAKT MHLMKLNAET
     PCVNLQLMNI RRCGHSESFF FIEVGRSSSI GPGEIWMQVD DSVVAQSMHE TILETMKALK
     AFAEFRPRSK SQSSGSNPIA FITTRRHLGN LPPSQTGLQR RSRTEMVVGT PPAGKSSTVN
     SYRFRTSSEG EGTMSRPYRS VTGSLIHLNS ARANLARPEG ASRYVRAMPS SNYHTRSASL
     PVSHFPSNTS PVSVSSSSGH GSASEALTRP SSASICGSPS DGGFASSDEY GSSPCDFRYF
     RVRSNTPDSL GNTPPIREEN SLSDYMAMDR HREAVGGAEG LQNETVFEER PTRKLTSSSR
     PPSSSSSVSA AIQKTTQTTP SLDEPDGSSF RRKALQAYSS PTKTGYSSFL DQYCETKPPL
     LQDDLQKPKD DGYMPMMPGV ASLRDTDYMP MQPHSRLPTS SFQQVDTQGY MMMLPRAGPS
     PAQTSPRGGG NRPRDGEYMD MSHGGGMHQA ESDGYYAPTP PETPKSYSSY FSLPRSYKAP
     ERDSHSEYVP MCSPAKVVLA EDECISSSPV KDLPTPLTLH NGCGELQHSD KHVVRPTRLS
     LDWQKASESP DAPAPPASPG EYINIDFRDR PAFTPCSMST DGSPSSLGST GEHRRSPLHE
     DYMSLETDSR PDQALSPKLS LVAPWNLPSY SRSPVLASML CSDGQVDDYT EMTFCSSEKG
     CELVVQPRDV GCHFPQLPPT SPKREPKVIR ADPQGRRRHS SETFTSTPAG ITCTSSSVLM
     PAGPHLADGA KWHGSVSFDS VLLQMEGVAT PDAGPSPALT EAGCAPGGRI YRNTSAGYQN
     GLNYIALDLR EEPQLSCGGS GTLLAVPPSP PASLSLAENG PYASIDFSEV LTSVSKE
//