ID   A0A3B3T3B2_9TELE        Unreviewed;       724 AA.
AC   A0A3B3T3B2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000037597.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000037597.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   AlphaFoldDB; A0A3B3T3B2; -.
DR   Ensembl; ENSPKIT00000018569.1; ENSPKIP00000037597.1; ENSPKIG00000015437.1.
DR   GeneTree; ENSGT01070000253775; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        71..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        99..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        165..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        198..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        240..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        365..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        428..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        459..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        486..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          501..694
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   724 AA;  80493 MW;  1C17E72095C6E2F8 CRC64;
     MRRPAHPYSV NRPVYSEDSF SEEHQNICRK HKTLQDHVKV YLRCDATRVK RVACSLLPII
     QWVRLYNVKK WLVGDLVSGV STGLVSVLQG LAYCLLASLP PWYGLYTAFF PVIIYFFLGT
     SRHISVGAFP VLSLMVGSVV TRLVPDEGPI ANITGFEGLT KDEQRVMVAA SVTFLMGIIQ
     LAFGLVQAGF IVTYLSDVLI SGYTTAAAIH ILVSQLKFVL GLNIKNYTGP LALIYTLEEI
     FAQIENSNIA SLVMSAIIIV VVFIVKELNE RFKAKLPVPL PIEVAITVIA CGVSYACKFV
     EKYDVDVVGK IPVGYEPPMA PSVEIFKLTV MDAFPMAIVA FAVAYSVAKV YAIKHEYTID
     GNQELIAFGV SNIFGATFRS FAASTALSRT AVQESTGGKT QVAGLLSAII VMIVTISIGF
     LLEPLPKAVL GAIVIINLKG MLMQMRVVGF LWKKDRPDCM VWLMTFGGSL LLGMDLGIPV
     GLAAELLALV FRTQFTLFSL IFSQIFAPSG VKIFRISTPI YFANVEFFRN KLNEYLGFNP
     LRVLRKRNKA LQKIKKLLKS GELQITEKGL LYMTSNSNED SDDEGNTEDL DQPSDYKDLP
     LQVNWNAELP ANMRVPKVDV HSVILDFAAV SFLDISAIKG LKSALKELIR VEVDVYIVAC
     DRYVLEKLHS CSFFDDEIKT SMFFLSLHDA MLHVMENHPI ILEYNTLNEK VSYYVNKYTN
     IFKA
//