ID A0A3B3T401_9TELE Unreviewed; 472 AA.
AC A0A3B3T401;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=RasGEF domain family member 1B {ECO:0000313|Ensembl:ENSPKIP00000037395.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000037395.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000037395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3T401; -.
DR Ensembl; ENSPKIT00000018359.1; ENSPKIP00000037395.1; ENSPKIG00000015496.1.
DR GeneTree; ENSGT00940000155816; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF197; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 34..164
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 204..452
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 472 AA; 54922 MW; 065F2D334D375361 CRC64;
MPQTPPFGSM FGPTGYNNNV YQSKEEGCGV LRYHDNNLVS GSLEALIQHL VPNVDHYPDR
TYIFTFLLSS RLFLHPYELM SKVYQMFVEH QRLGDPHADK IRVRKIAPKI VQLLTEWTET
FPYDFRDDRM MRGLKELTHR LTFGDEVCRK AVQQMMQGLI RKLAALSQYE ELLVKINATV
AERLTVLKTK PQSIQRDVLT VCNDAFSLAQ QLTHIELERL SYIGPEEFVQ AFVQKDPLVN
NKSRFSDRKK ANNLEVYVEW FNRLSYLVAT EICLPVKKKQ RARVIEFFID VARECFNIGN
FNSLMAIISG MNMSPVSRLK KTWAKVKTAK FDILEHQMDP TSNFYNYRTA LRGAMQRSIT
AHTSREKIVI PFFSLLIKDI YFLNEGCSNL LPNGHVNFEK FWELAKQVNE FMTWKQVECP
FERDRKILQY LLTAPVFSED ALFLASYESE GPENNMEKDS WKSLRSALLG RV
//
