ID A0A3B3TA99_9TELE Unreviewed; 411 AA.
AC A0A3B3TA99;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=SPARC related modular calcium binding 2 {ECO:0000313|Ensembl:ENSPKIP00000039699.1};
GN Name=SMOC2 {ECO:0000313|Ensembl:ENSPKIP00000039699.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000039699.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000039699.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; A0A3B3TA99; -.
DR Ensembl; ENSPKIT00000020710.1; ENSPKIP00000039699.1; ENSPKIG00000016937.1.
DR GeneTree; ENSGT00390000018436; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd16241; EFh_SPARC_SMOC2; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR037640; SMOC2_EC.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR PANTHER; PTHR12352:SF21; SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 2; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF16597; Thyroglob_assoc; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..411
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017449571"
FT DOMAIN 26..77
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 78..144
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DISULFID 115..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 124..144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 411 AA; 46061 MW; 57A90AC2EE6568DD CRC64;
KGQTMKNCLC VLYIFHISSS CQFLRVDQDR ECNMECSGAA RKPLCASDGR TFMSRCEFLR
AKCRDPQLEV IRGPCKETSR CVAEKKYTEQ QAKKVYPQVF VPVCNPDGTY NEVQCHSYTG
YCWCVTPNGR PISGSAVANK KPRCQGSKHE KVNTKEPGKA GKYFSKKDSF RFSGLVFVSM
ACSVYDIISQ YPTLWTEQVR SRQNNRTRTQ GGCISASSSC PSGTSAQRAG IFLQESGPAD
CFPSYPEMAC LLFCIPCRYE QPKCDGNARA HPTKPKDHFR SRHLQGCPGE KKTEFLTSVL
DALSTDMVHA VTDPASAARM LEPDPSHTLE ERVVHWYFSQ LDKNASGDIG KKEIKPFKRF
LRKKSKPKKC VKKFVEYCDI SNDKSLSLQE LMGCLGVTKE DGEHQGDGKR G
//
