ID   A0A3B3TCL8_9TELE        Unreviewed;       767 AA.
AC   A0A3B3TCL8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
GN   Name=AMPD3 {ECO:0000313|Ensembl:ENSPKIP00000040056.1};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000040056.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000040056.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
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DR   AlphaFoldDB; A0A3B3TCL8; -.
DR   Ensembl; ENSPKIT00000021074.1; ENSPKIP00000040056.1; ENSPKIG00000017137.1.
DR   GeneTree; ENSGT00950000183011; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF2; AMP DEAMINASE 3; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251}.
SQ   SEQUENCE   767 AA;  88539 MW;  3E3F2858B0EF7AF3 CRC64;
     MALTSSEDMP RQFPKISLSE VDEEVRLLAE KVYASALKEE DTKDALSMFS VPEDCPIGLQ
     QAKDYELLKE IAEQQSEESA KRKKSFKLIR SQSMSLQIPV STDWTFSMVS PLLSPASTCP
     SLPDNIPEFQ RVTISGDYCA GITVEDYEQA AKSLLKALFI REKYAKLAYH QFPRTTTQFL
     RSAENEKWRE EDEVLPDICP CPEEGEDPYS MVDIPENLNY ELKMKDGIIN VYDSAETLKL
     QRAHSLPYPD LETFAIDLSH VLAMIADGPT KTYCHRRLNF LASKFYLHEM LNEMAELKEL
     KGVPHRDFYN VRKVDTHIHA AACMNQKHLL QFIQNTYKME ADRVVQQKGG KKMTLKEVFD
     NLNMDPYDLT VDSLDVHAGR QTFHRFDKFN SKYNPVGASE LREIYLKTDN HIQGEYFARL
     IKEVAHDLQE SKYQYAEPRL SIYGRAPEEW ENLSKWFIQH RVHSPSMKWV IQVPRIYDIF
     KSRKLISNFA KMLENVFLPL FEATINPQKH KELHVFLKYV TGFDSVDDES KHSDHMFSYK
     SPKPEEWTTD SNPPYSYYLF YMYANIMVLN NLRKERGLNT FQFRPHCGEA GSITHLVSAF
     LTSDNISHGL NLKKSPVLQY LYYLAQVPIA MSPLSNNSLF LEYSKNPLRE FLHKGLCVSL
     STDDPMQFHY TKEALMEEYA IAAQLWKLST CDVCEIARNS VLQSGLSHQE KKHFLGVNYL
     KNGPEGNDIR RTNVAQIRMA YRHETLCNEL SFLVDAVKSA AIVAQSQ
//