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Database: UniProt
Entry: A0A3B3TCM6_9TELE
LinkDB: A0A3B3TCM6_9TELE
Original site: A0A3B3TCM6_9TELE 
ID   A0A3B3TCM6_9TELE        Unreviewed;       472 AA.
AC   A0A3B3TCM6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Zona pellucida sperm-binding protein 4 {ECO:0000256|ARBA:ARBA00040238};
DE   AltName: Full=Zona pellucida glycoprotein 4 {ECO:0000256|ARBA:ARBA00042573};
DE   AltName: Full=Zona pellucida protein B {ECO:0000256|ARBA:ARBA00042273};
OS   Paramormyrops kingsleyae.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX   NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000041032.1, ECO:0000313|Proteomes:UP000261540};
RN   [1] {ECO:0000313|Ensembl:ENSPKIP00000041032.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the zona pellucida, an extracellular matrix
CC       surrounding oocytes which mediates sperm binding, induction of the
CC       acrosome reaction and prevents post-fertilization polyspermy. The zona
CC       pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4.
CC       ZP4 may act as a sperm receptor. {ECO:0000256|ARBA:ARBA00037545}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}. Zona pellucida
CC       {ECO:0000256|ARBA:ARBA00024183}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR   AlphaFoldDB; A0A3B3TCM6; -.
DR   STRING; 1676925.ENSPKIP00000041032; -.
DR   Ensembl; ENSPKIT00000022062.1; ENSPKIP00000041032.1; ENSPKIG00000017712.1.
DR   GeneTree; ENSGT00940000163253; -.
DR   Proteomes; UP000261540; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   CDD; cd00111; Trefoil; 1.
DR   Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR   Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR   InterPro; IPR000519; P_trefoil_dom.
DR   InterPro; IPR044913; P_trefoil_dom_sf.
DR   InterPro; IPR042235; ZP-C.
DR   InterPro; IPR048290; ZP_chr.
DR   InterPro; IPR001507; ZP_dom.
DR   InterPro; IPR017977; ZP_dom_CS.
DR   PANTHER; PTHR23343; ZONA PELLUCIDA SPERM-BINDING PROTEIN; 1.
DR   PANTHER; PTHR23343:SF31; ZONA PELLUCIDA SPERM-BINDING PROTEIN 4; 1.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   PRINTS; PR00023; ZPELLUCIDA.
DR   SMART; SM00018; PD; 1.
DR   SMART; SM00241; ZP; 1.
DR   SUPFAM; SSF57492; Trefoil; 1.
DR   PROSITE; PS51448; P_TREFOIL_2; 1.
DR   PROSITE; PS00682; ZP_1; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00779}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Fertilization {ECO:0000256|ARBA:ARBA00023279};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          105..144
FT                   /note="P-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51448"
FT   DOMAIN          149..430
FT                   /note="ZP"
FT                   /evidence="ECO:0000259|PROSITE:PS51034"
FT   DISULFID        118..133
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00779"
SQ   SEQUENCE   472 AA;  51577 MW;  C4F6088885F702F8 CRC64;
     MLACFQSEGT TPADNDFWNI KVKGRQIISL ISFNTIGKMP SGPCDLFILS LARLCKTSDS
     VIYILVIDDA SFLQICLSLD NVKQDHSSLY EYPTCQSSIF CHPYTETEIQ SICDKVPCGG
     PAISKDACAA INCCFDGQQC YYGNAVTMQC TSDGQFVVVV AKDSTVPQLD VTSISMLGGK
     AAPCSPVATT DAFAIFTFPV TACGTVVKVG LYENRMSSSY EVGVGPLGSI TRDSLYELLF
     QCRYWGTEVV SLVAEYQPIA ADMPFPLVVP GPLRVELRLA NGQCYTKGCD EGAAAYTSYY
     QDSDYPVTKW LRQPVYVEVR LLSRTDPNLV LLLDSCWATP TPDPLSLPQW SLLETGCPNP
     GDKYLTTLVP VDGSSGLPFP TYYKRFIVQM FAFVDPASKH HLQGQVFFHC STAVCAPSAT
     DSCEQRCFRK VEGGVKTISP RGSIKYLFAC GEVENETANW SKEVLSGSFS HS
//
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