ID A0A3B3TEP5_9TELE Unreviewed; 1787 AA.
AC A0A3B3TEP5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000041757.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000041757.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSPKIT00000022796.1; ENSPKIP00000041757.1; ENSPKIG00000018084.1.
DR GeneTree; ENSGT00940000167352; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 177..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 244..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 440..467
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 578..596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 608..631
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 643..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 688..716
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 778..801
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1014..1032
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1053..1069
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1081..1101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1130..1156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1252..1278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1337..1355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1367..1385
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1397..1417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1454..1482
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1555..1581
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 180..473
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 577..807
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 818..1006
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1012..1287
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1336..1591
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 493..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..972
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1787 AA; 203799 MW; 411503AA5AA5D641 CRC64;
MNPKEMLLLD IWNRNRVRPV KRILKAKDLK ICPRLLPLLK DRNVVQSLAL QNAKMAKLLP
STSSDAFRRF TPESLAEIER RILEEKPEKS KDVEVAEEEL PKPSSDLEAG KVLPFIYGDP
PPEMMNIPLE DLDPFYKAQK TFIVISKGNT IYRFNAEPAC YFLSPFNIVR RSAIRVLIHW
LFSMFIMVTI LSNCVFMTMS NPPAWSKTVE YVFTGIYTFE ATIKILSRGF CIGSFTFLRD
PWNWLDFMVI TMAYVTEFVD LGNVSALRTF RVLRALKTIT VIPGLKTIVG ALIQSVKKLA
DVMILTVFCL AVFALVGLQL FMGNLRHKCI RWPPATNSSW LFNSTEDVNA TQFDFTEYID
DIDNHYFLEG QVDALICGNS SDAGKCPEGY TCMKAGRNPN YGYTSYDSFG WAFLALFRLM
TQDFWENLFQ LTLRAAGKTY MIFFVVIIFL GSFYLINLIL AVVAMAYAEQ NEATIAEAKE
KEEEYQKIME QLKKQEAQGR PDVKDEKLSR EHLEEPGKQS RKASDASDVA NVLEDLEEGQ
RPCPPRWYKF ANNFLKWDCC TAWIVFKKWT YFVVMDPFVD LGITICIVLN TLFMAMEHYP
MSESFAEMLS VGNLVFTGIF TAEMVFKLIA MDPYYYFQVG WNIFDSIIVT LSLVELGLAN
VQGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL
FGKNYKDCVC KISSDCELPR WHMTDFFHSF LIVFRILCGE WIETMWDCME VAGQGMCLVV
FMMVMVIGNL VVLNLFLALL LSSFSGDNLS ASDEEGENNL QIAINRITRG INFIKAYIIG
LIRRMLGRKA KSNEGDGEDD NSKKENLMLN HMNADADPKT NLQMMESSST LTDGVSSIDF
VTNAKVTVNI PIAKSESDLD IPNDYDYSSD DETGIIKKKV EEVADNAVQS VTEEKVPEEE
EEPEEEPDMI EPEPCFTDAC FSRFPFLMVD VTEGKGKIWW NIRTTCLTIV EHNYFESFII
FMILLSSGAL AFEDVYIEQR RVIKILLEYA DQVFTYVFIV EMLLKWVAYG YKVYFTNAWC
WLDFLIVDVS LISLTANLLG YSELGPIKSL RTLRALRPLR ALSRFEGMRV VVNALVGAIP
SIFNVLLVCL IFWLIFSIMG VNLFAGKFYY CLNVTAGEIF PLDIVNNKTE CFALMEQHDD
VRWVNLKINF DNVGMGYLSL LQVATFKGWM DIMYAAVDSR EVEDQPEYEV NIYMYLYFVI
FIIFGSFFTL NLFIGVIIDN FNQQKSKFGG QDLFMTEEQK KYYNAMKKLG SKKPQKPIPR
PLNPVQGLVF DFVTKQFFDI FIMIMICLNM ITMMVETDDQ SEDKEMILFY INLIFIVVFT
AECVLKMFAL RQYFFSAGWN IFDFVVVILS IVGLLLADII EKYFVSPTLF RVIRLARIGR
VLRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLIMFIFS IFGMSNFGYV KKEAGIDDIF
NFETFGNSII CLFEITTSAG WDGLLLPIMN SGPPDCDPDI ENPGSSVRGN CGNPAVGIVF
FCGYIIMSFL VVVNMYIAII LENFNVATEE SSEPLCEDDF EMFYETWEKF DPDATQFLDY
SRLPDFCETL KDPLRIAKPN KIKLITMDIP IVTGDKIHCL DILLALTTEV LGESDAMGAL
RESMEEKFKM NNPSPVVYEP ITTTLRRKRE EVAATVIQRA YRKYLSDPSG KCVPSKLKGP
MNKKKERPVE NFLLNRVEFV SDVVLHAAPS PPEEALTSLD NLKESVV
//
