ID A0A3B3TEZ0_9TELE Unreviewed; 3420 AA.
AC A0A3B3TEZ0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Dystrophin {ECO:0000256|ARBA:ARBA00040142};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000041857.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000041857.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in anchoring the cytoskeleton to the plasma
CC membrane. {ECO:0000256|PIRNR:PIRNR002341}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004278}. Cytoplasm, cytoskeleton
CC {ECO:0000256|PIRNR:PIRNR002341}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034100}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034109}.
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DR STRING; 1676925.ENSPKIP00000041857; -.
DR Ensembl; ENSPKIT00000022899.1; ENSPKIP00000041857.1; ENSPKIG00000017543.1.
DR GeneTree; ENSGT00940000154342; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00176; SPEC; 9.
DR CDD; cd00201; WW; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 1.20.58.60; -; 14.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR035436; Dystrophin/utrophin.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF25; DYSTROPHIN; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00435; Spectrin; 14.
DR Pfam; PF00569; ZZ; 1.
DR PIRSF; PIRSF002341; Dystrophin/utrophin; 1.
DR SMART; SM00150; SPEC; 21.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 17.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|PIRNR:PIRNR002341};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR002341}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002341};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR002341};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002341};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Postsynaptic cell membrane {ECO:0000256|PIRNR:PIRNR002341};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|PIRNR:PIRNR002341};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 2763..2796
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 3016..3072
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 134..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3239..3261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3313..3334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3401..3420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 454..488
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 850..880
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1017..1044
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1539..1566
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2232..2266
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2318..2365
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2651..2688
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3277..3311
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 146..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3420 AA; 393733 MW; BBFC52AD86706678 CRC64;
MLYRSRKLCK FNIVLHLCKE TDFVYFLKYI KNKYSSLSSV SDVATTHPDK KSILMYVTSL
FQVLPHGVTM EALREVERLP PAPMALEDHV QSKQRFSQQI TVNVAQGWVR SPSPTAKPRY
KSYAYTQAAY VKSPEQKRRR FTSQSPDSQG EEASSSPNPH RDLQLERYQT ALEEVLTWLL
SAEDSLQSQS PISNQVEVVK EQFHTHEGYM VELTSHQGSV GRVLQSGSML LAEGRLTEEE
ENEIREQMNL LNSRWEHLRV ASMERQSRLH EVLMDLQNQQ LKQLTDWLEL TEGRINRMEA
QPLGPDLVDI KHQVEEHKLL QEDLEMEQVR VNSLTHMVVV VDESNGDSAT AALEEKLQHL
GDRWAAICKW TEERWVLLQE ILLKWQQFTE EQCSFDTWLV EKEEFVHTIQ CSGLKEQSGM
VESLRKLAIV KGELEAKRQT MDRLCSLSQD LLSSVKNKDL ARKLEARLEN LTQRWESLLQ
KLEKSSSQIS MSVTTAQTEL MKTTVMSSVT KVTTRGQVVV THTKEEVAPP LPQKKRQIVV
DSELRKRFDV DFTELHSFMT RSEAILQSPE FSFSRKEGSV SELQEKVLAI EREKPEKMRK
LLEATRSAQA VVDQLASEGL KADDIKQAAD QLNSRWVEFC ALLDERLAWL AYQTKVLAFY
NQFQQLEQAV VTAENWLKVQ QPPASELEPL RIQVDRCKDE VARLSALQPQ VNQLKEQVKD
LREKEEAPVF FDADIKALTD HYKQVLADLQ ARLSQLQLIQ DSLPPVRYRD TATSLFAWLQ
QCEAQLPVPS TAVNEYPIME QRLKDMKALQ VSLQEHQSSL DYLTVTVEQV CQKAPYEISQ
KYRMELDAIM MRWKRMSTQL EEQIQRLQEL MAKLQQFQND TKTLRKWMVE VDVFLNEEWP
ALGDSEALEK QLEQCTALVN DINTIQPSVN GINEVGHALK KEAEPVFASK LQEEITQLNA
QWENICKQAY AKKSALKGGL DKTVSLRKDL SEMQEWITQA EEEFLERDFQ YKTPEELRKG
VEEIKRAQEE VHQKEVKVKM LTDSVNSFIA KAPPVAHEAL KTELNILTTN YQRLCSRLDG
KCKTLEEVWS CWCELLSYLG LENGWLDQLE NKLNETESIH GGAEEISEAL DSLESLLRHP
EDNRNQIREL AQTLMDGGVL DELINQKLEA FNTRWDELME RAAQRQKCLE MSIQSAQEHD
KALRLIQESL HTTDRHLSAY IADHLDAGQL PQEAQKIQTE LNSHELSLDE MRKKNANKDP
SDRVYSQIDI TQKKLQEVIK KFRLFQKPAN FDERLQVCER VLDEVKTQLG VLGVRSVDQE
VVQSQLDQCM RFYKSLSEVK AEVETVIKTG RQIVQRQQTE NPKDLDERLT ALKLLYNELG
AQVTESKQEL EKSLKLSRKL RKEVNSLTEW LAVTDAELTR RSDVDGMPDS LGAEVAWAKA
KQKETEQHEQ QLKGVAELAD ALKAVLQGQE SLVEDKVSLL KCNWIAVTSR SEEWLHLLLD
YQSQVDTLDQ NISQINAWMH RSETLLDESE PLGTKDHVIK GLRVELEDMR AKLEAVQSQA
QEMMKNQGEH CRALVEPKLD QLNQRFEAIA RRIRTSQVTA SEREVEQYHS EAMIWLRLLD
EEVRQGDNLK EEDFEQDRDC EEGAVKELLE KGEKLQKRVP DENKRKEIRI RHDQLNTKYN
TVKDLRSLRK KKALAIAPQW YQYRRKSDDL LQWLDDIERS MAELTDPPEE QRVKVWRAEE
RPHRPALSDL QVQAKVLADG GAAQLVDPRL AQLNKRWGEV QSTFAPYHHS KDKTLFVFLL
GDSNILKILL QHSYLCELQE LLHSIANTEF QLNSPEYWAG VFYELPKQEK CLQVGSSVLE
KLGTPVVRAQ GRKEEILRKA SPVEAQRIQD TLLLLSTNWE KVNKLYCDRL AYLSQDKLQH
FNKNLKALSE WLGDAERSLA QAERQPVQRR EHLKELQDAA SAQESAMIAL NTTGQDIILQ
SSQEEGARLK EQLGSMNKRW EEVCRQFAQW KRRSAEMHNT VSDLQEDLSE FLSWLDDAEN
VAAIAPHPGD QQQLSSLLEK VQARVQEVPN RKLNLKELND RGCSVHALLC RLNLPYQVSR
DLPEKQQQIE GLLKDLSQFH LELSQLSQWA AGFKDQLELS RQAADNKFSV PNLSLCAFPP
FLQVKFEGLS TDWRIIQDLL KEMKMKSQPT TTVIRETIPA LVQFNKTLSE LTNWLSVLDH
MTQTQRVMVG NLEEINDMMK KQKATLQDLE QRRPQMESQI TAAQNLKNKT NNQEARVTIT
DRIDRLQTQF EEVHGRLSDR ALELQRMLKD SSHWLKAKQE VESLLKRANE KLESWKELSY
TVDALKNQNA DLKHFVKELH QWQRQVDETN DLARKLLVQY AADDTHRVSM LTDSMNSTWS
HVTKQVGERE AALEAALRLL QQFYLDLEKF LNWLAEAETT ANVLQDATHK EGMQEDPSAG
RQLLRQWQDL QTEIEAHTEA FHTLDENGQR IMRSLEGSED AALLQRRLDN MDQRWNELRS
KSLSIRSHLD AGTGQWKCLH LSLQELLTWL QQKNEELDHM APTGGDIPMV QQQLEAHRAF
RIEVKAKEPA VSGALNAVGA FLADQHTETS LLGRVASAEV SPEERAQNMS RVLRKEAEDV
RSGWERLRSR SVSWQRRLDQ ALEHLQELQE AEDKLDLKLR QAEMVKQSWE PVGDLLIDSL
QEHIDRVTAF QAEVAPIKDD LTQVNCFAST FCPMNIQLSE YNINRLEDLN TRWRLLQVHN
RHASVQHPFE RSVSPNNVPY YINHQAQTTC WDHPKMAELY QSLADLNNVR FSAYRTAMKL
RRLQKALCLD LLGMSAACEA FDQHNLKQNE QLLDIMQIIN CLTSIYNRLE QQHSNLVNVP
LCVDMCLNWL LNVYDTGRTG KIRALSFKTG IISLCKAHLE DKYRFLFRQV ASATGFCDQR
HLGLLLHDSI QIPRQLGEVA SFGGSNIEPS VRSCFQFANN KPELEAAVFL DWMRLEPQSM
VWLPVLHRVA AAETAKHQAK CNICKECPII GFRYRSLKHF NYDICQSCFF SGRVAKGHKM
QYPMVEYCTP TTSGEDVRDF AKVLKNKFRT KRYFAKHPRM GYLPVQTVLE GDNIETPVTL
INFWPVDYAP TSSPQLSHDD THSRIEHYAS RLAEMETRNG TCISDGISPN ESIDDEHLLI
QHYCQSLNQE SPLSQPRSPA QILISLETEE RGELERVLSD LEEENRNLQA EYDRLKQAHD
RKGLSPLPSP PEMLPVSPQS PRDAELIAEA KLLRQHKGRL EARMQILEDH NKQLESQLQR
LRQLLEQVDT KLNGTTALSS PSTSSQRSDS SLPHLRVVAS QTTETMGDDE LSSPSQDTST
GLEEVMEQLN NSFPHTQGHA VGSLFHMADD LSRAMESLVS VMTAEQGQEE RRAPPPSMLL
//
