ID A0A3B3TEZ8_9TELE Unreviewed; 294 AA.
AC A0A3B3TEZ8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Secreted frizzled-related protein 2-like {ECO:0000313|Ensembl:ENSPKIP00000041245.1};
OS Paramormyrops kingsleyae.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC Osteoglossomorpha; Osteoglossiformes; Mormyridae; Paramormyrops.
OX NCBI_TaxID=1676925 {ECO:0000313|Ensembl:ENSPKIP00000041245.1, ECO:0000313|Proteomes:UP000261540};
RN [1] {ECO:0000313|Ensembl:ENSPKIP00000041245.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR AlphaFoldDB; A0A3B3TEZ8; -.
DR STRING; 1676925.ENSPKIP00000041245; -.
DR Ensembl; ENSPKIT00000022278.1; ENSPKIP00000041245.1; ENSPKIG00000017873.1.
DR GeneTree; ENSGT00940000156432; -.
DR OrthoDB; 4814466at2759; -.
DR Proteomes; UP000261540; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF45; SECRETED FRIZZLED-RELATED PROTEIN 2; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..294
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017450895"
FT DOMAIN 34..154
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 171..294
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 49..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 86..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 117..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 294 AA; 33873 MW; C923E6945FFE5E7A CRC64;
MKYFTLIIIS VTALPACMEA IHGIYPFGQP ELFHKKSNCK PIPVNLQLCH DIEYTDMRLP
NLLGHETMNE VLQQASSWIP LVQKQCHPDT RKFLCSLFSP VCLDDVDEPI QPCRSLCERV
RNGCAPVMSA FGFPWPDMLD CDRFPPENDL CIPPANFDSF EPVTQEVPRV CEPCQEKEEN
DNEIVDNLCK NDFALKIKVK EISYMNGDTK IIPENKIRTI YKLKGVTERD LKKTVLWLKD
GFKCTCDEMN DFSTAYLVMG QKMDGHLVIT SVKRWQPGQK EFKRISRSIR KMQC
//
