ID A0A3B3THI4_9TELE Unreviewed; 814 AA.
AC A0A3B3THI4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN14 {ECO:0000313|Ensembl:ENSPLAP00000000127.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000000127.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000000127.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR AlphaFoldDB; A0A3B3THI4; -.
DR STRING; 48699.ENSPLAP00000000127; -.
DR Ensembl; ENSPLAT00000016936.1; ENSPLAP00000000127.1; ENSPLAG00000000899.1.
DR GeneTree; ENSGT00940000156874; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 3.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}.
FT DOMAIN 21..299
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 536..807
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 717..798
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 458..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 748
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 814 AA; 94064 MW; 4268A85BB68EBED7 CRC64;
MPFGLKLRRT RRYNVLSKNY FVTRIRLLDN NVIECTLSVE STGQECLEAV AQRLELRETH
YFGLWFQGKT QTPAQRWVEL EKPLKKQLDK FGNEPQLFFG VMFYVPNVSR LEQEATRYQY
YLQVKKEVLD GHLQCTVERG IRLAGLAVQA DFGDFTHFPS QDFLREYVLF PVVMLEEWTK
KVAEEHKSHC GRPPAEAELL YIKEVEKLDG FGQESFPAKD NYTNDIFIGM SFVGVFVKHR
NGRSIMWKDI GTIAHNKSAI TVEITSRDDT INFHMEDMEM AKYIARLFTA RHKFYKQNKI
CTEPTHSPAP IRRRPTWTHR LSLVYHIFHE DLYYKSETSL DLTFRNGTVP NGSMYSSPSL
SSLNRSQTFI PPSPMSSNLS IPGSELMRQD YIPNHRHSAI IAPSYRPTPE YEAVMRQKRR
VVPAHHDLHS QSLRSLNISN ACAYRKPEAL VYSQPEMRER GPYHGPGPNP GPYTPQTLER
QKMSVDSMRR PLMMAALNGL YVARMPVARN QAEEGAKSTS DERCETLELK LEEDRVFTEY
EQVPKKRTDC LLTTATLPEN AERNRFRDVI PYEENRVELV PNKENNTGYI NASHIKVRSV
GEEWHYIATQ GPLANTCGDF WQMIWEQGVN VIAMVTAEEE GGRSKSHRYW PKLGSKHNSA
TYGKFKVTTK FRTEYNSYAT TGLKVKHLLS GQERTVWHLQ YTDWPEQGCP EYVPGFLSYL
EQIQSVRRHT NTMLDTSKSL NPPVVVHCSA GVGRTGVVIL AELMISCLEH NEPVEVPTML
SELRHQRMLM VQTISQYKFV YQVLIQFLKN SRLI
//
