ID A0A3B3TIU3_9TELE Unreviewed; 474 AA.
AC A0A3B3TIU3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4-like {ECO:0000313|Ensembl:ENSPLAP00000000256.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000000256.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000000256.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: In the C-terminal section; belongs to the phosphoglycerate
CC mutase family. {ECO:0000256|ARBA:ARBA00008408}.
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DR RefSeq; XP_014905779.1; XM_015050293.1.
DR AlphaFoldDB; A0A3B3TIU3; -.
DR STRING; 48699.ENSPLAP00000000256; -.
DR Ensembl; ENSPLAT00000016724.1; ENSPLAP00000000256.1; ENSPLAG00000001060.1.
DR GeneID; 106958409; -.
DR KEGG; plai:106958409; -.
DR CTD; 386663; -.
DR GeneTree; ENSGT00950000182835; -.
DR OrthoDB; 2013830at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001345; PG/BPGM_mutase_AS.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR PANTHER; PTHR10606:SF14; 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 4; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00175; PG_MUTASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 40..254
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT BINDING 261..268
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 311
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 474 AA; 55277 MW; 2154D0152630E247 CRC64;
MLDNEDHLLE NHPRELTQNP LKKIWMPHKN SHIGHRRVCM TNCPTLIVTV GLPARGKTYI
SKKLTRYLNW IGVPTKEFNV GDYRRECLKI YKSFEFFRPD NEEGVKIRRQ CAMSALNDVR
QYLSVEGGQV AVFDATNTTR DRRGTIMKFA EQNGFKVFFV ESVCEDPEVI AQNIVQVKLG
NPDYMNCSSE EAIEDFMERI KCYETSYQPL DEDLDSDVSY IKIMDVGRRY LVNRVVDHIQ
SRIVYYLMNI HITPRSIYLC RHGESDLNIK GRIGGDSGLS SRGKEFAKRL RSFLEEQKIK
DLKIWTSQMK RTIQTAECLG VPYEQWKSLN EIDAGVCEEM MYEEIQEHFP LEFALRDQDK
YRYRYPKGES YEDLVQRLEP VIMELERQEN VLVICHQAVM RCLLAYFLDK TSHELPYLKC
PLHTVLKLTP VAYGCKVESV YLGVESVNTH RDRPENVNVQ RSTEDALQTV PAHL
//
