ID A0A3B3TK17_9TELE Unreviewed; 551 AA.
AC A0A3B3TK17;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Estrogen receptor beta-like {ECO:0000313|Ensembl:ENSPLAP00000000992.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000000992.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000000992.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR002527}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC subfamily. {ECO:0000256|ARBA:ARBA00005413,
CC ECO:0000256|PIRNR:PIRNR002527}.
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DR RefSeq; XP_014877632.1; XM_015022146.1.
DR RefSeq; XP_014877634.1; XM_015022148.1.
DR AlphaFoldDB; A0A3B3TK17; -.
DR STRING; 48699.ENSPLAP00000000992; -.
DR Ensembl; ENSPLAT00000015504.1; ENSPLAP00000000992.1; ENSPLAG00000001942.1.
DR GeneID; 106939661; -.
DR KEGG; plai:106939661; -.
DR CTD; 317734; -.
DR GeneTree; ENSGT00940000156116; -.
DR OrthoDB; 5387678at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1903924; F:estradiol binding; IEA:Ensembl.
DR GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:Ensembl.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:1990239; F:steroid hormone binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:InterPro.
DR GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IEA:InterPro.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR CDD; cd07171; NR_DBD_ER; 1.
DR CDD; cd06949; NR_LBD_ER; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR021064; ER-beta-like_N.
DR InterPro; IPR028355; ER-beta/gamma.
DR InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092:SF12; ESTROGEN RECEPTOR BETA; 1.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF12497; ERbeta_N; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF500102; ER-b; 1.
DR PIRSF; PIRSF002527; ER-like_NR; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002527};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR002527};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR002527};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR002527}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 147..222
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 267..503
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 508..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 61287 MW; A671C80E89401C59 CRC64;
MAAATSPEKH QPLLQLQEVD SSRVGGRILS PGLTHEACQP ICIPAPYTDL GHDFTSIPFY
SPTIFSYASQ SISECPSVHQ SLSASLFWPR SGHVGAALPL HRSSGRAQHG QAVQHPWESV
LTSRKSTKKL SQENEDAVVS SGGKGDLHYC AVCHDYASGY HYGVWSCEGC KAFFKRSIQG
HNDYICPATN QCTIDKNRRK SCQACRLRKC YEVGMTKCGI RKERGNCRST LVRRVTRLSA
QGRISRPKVL TRPVESPSNE PLQPGMTPEQ LIERIIEAEP PDIYLMKDMK RPLTEADVMM
SLTNLADKEL VHMIGWAKKI PGFVELCLLD QVHLLECCWL EVLMMGLMWR SVDHPGKLIF
SPDLCLSREE GSCVQGFAEI FDMLIAATSR VRELKLTREE YVCLKAMILL NSNMCLSSNE
GSEELQSRSK LLRLLDSVTD ALVWAIAKSG LTFRQQYTRL AHLLMLLSHI RHVSNKGMDH
LHCMKMKNIV PLYDLLLEML DAHIMHSSRL PRRPAQQEST DQPAAAAASG GPSNTWTPSS
AGGGVEAQCS D
//
