ID   A0A3B3TKF3_9TELE        Unreviewed;       817 AA.
AC   A0A3B3TKF3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=DNA helicase MCM8 {ECO:0000256|ARBA:ARBA00041084};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE   AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN   Name=MCM8 {ECO:0000313|Ensembl:ENSPLAP00000001117.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000001117.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000001117.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC       ECO:0000256|RuleBase:RU004070}.
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DR   AlphaFoldDB; A0A3B3TKF3; -.
DR   Ensembl; ENSPLAT00000015294.1; ENSPLAP00000001117.1; ENSPLAG00000002113.1.
DR   GeneTree; ENSGT01090000260080; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR   CDD; cd17759; MCM8; 1.
DR   CDD; cd22247; MCM8_WHD; 1.
DR   Gene3D; 2.20.28.10; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR   PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50051; MCM_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004070}.
FT   DOMAIN          400..588
FT                   /note="MCM"
FT                   /evidence="ECO:0000259|PROSITE:PS50051"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   817 AA;  89231 MW;  12D1BB0EBD9CDE8E CRC64;
     MSTEGTSRGS WRGGNKGWRG RGNGGWRGRG NGGWRVQGGW RRPWRGGSAA GGGGSRGGGV
     SGNPSLSSQR GELHYYFCFI ESSPTVEKIK VFEKYFISQI HLYDKDEIER QGSVLVDYTD
     LTGNKAVCEA LTDIVTDLRE QPDVILNCLG VAIHQVLTAD LEKQAAELQD EELPVATPII
     NIPHISVRLY NYEPLTPLRT LRASVFGRMV CVRGTVVRVS NIRPQCTRMA FKCQTCTSTL
     TLPLQHGKYA TPTKCIQPGC RTRSFIPLRS SPSTKTVDWQ IIKVQELMGG EQRETGRIPR
     TVECHLTSDL CDSCVPGDAV TVTGIVRVIN DGNKDQCMFL LYIEATSVSN TKGTGSREDR
     TGGEEFSLKE LYAIQEIQSQ PNLLRLIVVH AGFPVCWQLV KAGLALALFG GRQKHTDKSS
     VPVRGDPHIL VVGDPGLGKS QMLQAVCNVA PRGIYVCGNS TSTTGLTVSL SRDSGTGDYA
     LEAGALVLAD QGLCCIDEFD KLGSQQQALL EAMEQQSVSL AKAGIVSSLP ARTSVVAAAN
     PVGGHYNRGK TVSENLKMGS ALLSRFDVVF LLLDIPDESH DRQLSEHVMA NRAGKGRTSS
     ATVTRISNDP ETSILLQHAA MPLSERLQFP ANESADVIPT CLLRKYISYA RQYVRPTLCP
     EAAKTLQDFY LSLRSQAHSA DATPITTRQL ESLVRLTEAR AKLELREVAT QSDAEDVVEI
     MKHSLADTYS DGLGNLDFER SQLGSGMSQR GAAKRLVSAL HSHAQRTNQK QFDLQTIRSV
     ADKMNIKVMD FQGLLSSLNE QGFLLKKGPK LYQLQTM
//