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Database: UniProt
Entry: A0A3B3TKZ5_9TELE
LinkDB: A0A3B3TKZ5_9TELE
Original site: A0A3B3TKZ5_9TELE 
ID   A0A3B3TKZ5_9TELE        Unreviewed;       734 AA.
AC   A0A3B3TKZ5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Chloride anion exchanger {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 3 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A3 {ECO:0000313|Ensembl:ENSPLAP00000000934.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000000934.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000000934.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Mediates chloride-bicarbonate exchange with a chloride
CC       bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a
CC       role in the chloride and bicarbonate homeostasis during sperm
CC       epididymal maturation and capacitation.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   AlphaFoldDB; A0A3B3TKZ5; -.
DR   Ensembl; ENSPLAT00000015606.1; ENSPLAP00000000934.1; ENSPLAG00000001905.1.
DR   GeneTree; ENSGT01070000253775; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF19; CHLORIDE ANION EXCHANGER; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU362052};
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        74..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        101..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        127..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        166..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        192..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        220..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        251..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        367..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        462..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          517..710
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
SQ   SEQUENCE   734 AA;  81665 MW;  ABAC0A266BC66612 CRC64;
     ESEDLELLQY VVARPLYSED SFNEEHKKVY RHHKTALDHV KQYFRCDAKR AKNAALSLLP
     IIGWMKIYRI KEWLLSDIVS GVSTGLVAVL QGLAYCLLAS LPPWYGLFAA FFPIIPYFFL
     GTSRHISVGP FPVLCLMIGS VVTRLIPDEG PAANITGFSG LTVDEQRVLV ASSVTFLVGI
     MQLAMGILQV GFVVMYLSDT LVSGFTTAAA IHILVSQLKF VLGLQVPGIS GPLSLIYTLE
     IIFKKITSSN VCDIVISLVI MVTVFLVKEL NDRYKSKLPV PIPIEVIMTV ITCGVSYAFD
     FRTRYGIDVV GKIPLGYEPP VAPNLQVFQH TAMEAFPMAI VGFAVAFSVA KVYSIKHDYT
     IDGNQELIAF GVSNIFGASF KAFAASTTLS RSAVQESTGG KTQIAGLLSA VIVMIVTLAI
     GYLLEPLPKS VLGAVVIINL KGMLMQFNEI PYLWRRDRPD CVVWMVTCGA AILLGLDLGL
     AVSLGVELIC VVLRVQFPRC SVLANIEGTE IYKDRKDYIS INEPEGVKIF RIPSPIFFAN
     MDFFRNKLVE ALGFNPLRVL KKRNKALSRI RKLLKKGDLQ WTSKGFLNTT NGSLVDPLED
     SDNEELDKPI DFKDLPIRID WNAELPANMV VPRVDIHSLV LDFAAVSFLD ISGLKGLKTL
     LKELVRVEVE VYIVACDPYI LEKLHKCCFF DEEVQPSMFF LTLHDAMLHI LEKHPETTER
     KTYYKNFYGS ILNS
//
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