ID   A0A3B3TLF2_9TELE        Unreviewed;       676 AA.
AC   A0A3B3TLF2;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Receptor interacting serine/threonine kinase 1 {ECO:0000313|Ensembl:ENSPLAP00000001094.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000001094.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000001094.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_014889872.1; XM_015034386.1.
DR   RefSeq; XP_014889873.1; XM_015034387.1.
DR   AlphaFoldDB; A0A3B3TLF2; -.
DR   Ensembl; ENSPLAT00000015333.1; ENSPLAP00000001094.1; ENSPLAG00000002068.1.
DR   GeneID; 106948613; -.
DR   KEGG; plai:106948613; -.
DR   CTD; 567460; -.
DR   GeneTree; ENSGT00940000159347; -.
DR   OrthoDB; 3997405at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:UniProt.
DR   GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR   GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR   GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR   GO; GO:0006950; P:response to stress; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR025735; RHIM_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR23257:SF983; RECEPTOR INTERACTING SERINE_THREONINE KINASE 1; 1.
DR   PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF12721; RHIM; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          16..289
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          586..672
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          425..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..459
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  76292 MW;  2D96AA09A366DEF1 CRC64;
     MATAPEISLH MRSADLIKRE PLDYGGFGEV YLCYHATLGQ VVLKTVYTGP LRNEENKKSL
     LEEGSIMASL NHKRVVKLLG VIMEDRDCSL IIELLPRGNL LVMLEKVAVP ISIKGRIILE
     ILEGMVYLME RHVIHKDIKP ENILVDKDFH IKIADLGLAT CQAWNKLTRQ ESRRKSHRGA
     TSGDRGAGTL SYMAPEHLES INTPSSVKSD VYSFAIVVWV ILTGKEPYEN ARSDDHISQC
     VRHGDRPAVE LIPEDTPAEI IDLMKRCWAQ DPIERPTFQE AYDNFLPFYK EKLEPLVEED
     VCLLQEQYEG PDELVEKIKS LSMTHDSFSA TDQDGPASLS SHRDLSMPVE ASIEDLHNIN
     DQPSGDPLET DARMLRTPSE LEEKLDREFN YHKHGSYACN NQPESAQGLQ RNPSNPFFRN
     PFNFSDNGLR LPAEENSSVH SWTKPEQEQP TSQTEAYRRP TSDLYGSITS YSSNHSLLHP
     SFSTPSLSQF DQQQPRSLDR QQSCPIYPVS DTFDPNRNAG NNLTSSKSGS MQETGSLYIC
     NASGIQIGNN NTMSIRSSEL SQGLFDGNTA SSIQESIFKY ADHVVKESQL EVLRENIGMK
     WKRCARRLGL TEVEIETIEH DYYRDGLPEM VHQMLESWKR KQGSLNCTIG RLCQALQGNI
     KVDVIQKILD LCDSSE
//